{"id":"W3092010049","doi":"10.1177/0192623320960420","title":"Long-Term Nonclinical Pulmonary Safety Assessment of Afrezza, a Novel Insulin Inhalation Powder","year":2020,"lang":"en","type":"article","venue":"Toxicologic Pathology","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nuclear Laboratories","funders":"","keywords":"Inhalation; Proliferating cell nuclear antigen; Pathology; Eosinophilic; Histopathology; Inhalation exposure; Respiratory tract; Medicine; Carcinogen; Mucus; Hyperplasia; Respiratory system; Chemistry; Immunohistochemistry; Internal medicine; Anesthesia; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000447483,0.0001806476,0.0005663504,0.0001021524,0.00006335609,0.00000442085,0.0001239721,0.000416464,0.0008556159],"category_scores_gemma":[0.0003770084,0.0001462381,0.0001605269,0.0002483467,0.0002441441,0.0000612802,0.0001278068,0.0004550684,0.00008301131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007307125,"about_ca_system_score_gemma":0.0002423107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":6.971727e-7,"about_ca_topic_score_gemma":0.000001066371,"domain_scores_codex":[0.998161,0.0002051166,0.000738229,0.0004061895,0.0002378064,0.000251634],"domain_scores_gemma":[0.9989326,0.0001838097,0.0002809444,0.0002539706,0.0001598012,0.0001888727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001099074,0.002673111,0.392521,0.0002549031,0.0001047718,0.002292526,0.0004764556,0.0002570963,0.5819372,0.001093433,0.0002869152,0.01700353],"study_design_scores_gemma":[0.002721752,0.001719082,0.9882624,0.00003482932,0.0000970169,0.0003851521,0.00006547583,0.003059073,0.002882032,0.00001621419,0.0005757681,0.0001812093],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792089,0.0001722975,0.005157,0.004216246,0.0002598364,0.0005453293,0.00002825563,0.0001010403,0.01031108],"genre_scores_gemma":[0.9896581,0.00006876649,0.002117863,0.007613576,0.0002579107,0.00001908542,0.00008234139,0.0000169448,0.0001653734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5957414,"threshold_uncertainty_score":0.9368395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06544501687616108,"score_gpt":0.3523602432414032,"score_spread":0.2869152263652421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}