{"id":"W3092010049","doi":"10.1177/0192623320960420","title":"Long-Term Nonclinical Pulmonary Safety Assessment of Afrezza, a Novel Insulin Inhalation Powder","year":2020,"lang":"en","type":"article","venue":"Toxicologic Pathology","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nuclear Laboratories","funders":"","keywords":"Inhalation; Proliferating cell nuclear antigen; Pathology; Eosinophilic; Histopathology; Inhalation exposure; Respiratory tract; Medicine; Carcinogen; Mucus; Hyperplasia; Respiratory system; Chemistry; Immunohistochemistry; Internal medicine; Anesthesia; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007044573,0.0004773977,0.0003699827,0.0003082035,0.0002571483,0.0003441627,0.0003471904,0.0005274008,0.001044517],"category_scores_gemma":[0.0004267237,0.0001586569,0.0005376862,0.0001819871,0.0002755591,0.0003726661,0.0001871846,0.0005735494,0.0002433444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002249153,"about_ca_system_score_gemma":0.0003336581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004086656,"about_ca_topic_score_gemma":0.0007776153,"domain_scores_codex":[0.9996587,0.0001062357,0.0000183227,0.00006971411,0.0001178797,0.00002916511],"domain_scores_gemma":[0.9995147,0.00007144993,0.0001914322,0.00005340106,0.00009472116,0.00007430057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007488169,0.003593598,0.008291708,0.0002213245,0.000141647,0.0003496478,0.0001132515,0.0005092314,0.9440255,0.000073758,0.0002277507,0.0349644],"study_design_scores_gemma":[0.0009242588,0.2487945,0.04988084,0.00005256305,0.0005163239,0.001980888,0.0003071328,0.001975245,0.6887311,0.0001014549,0.006696927,0.00003873384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960751,0.001330927,0.001794698,0.00005394725,0.00002141296,0.0001211136,0.0001244605,0.00003103471,0.0004473478],"genre_scores_gemma":[0.9942141,0.001602706,0.001814882,0.0001205879,0.00002956782,0.0001002023,0.0004070423,0.00001604187,0.001694907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001044517,"threshold_uncertainty_score":0.003725529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06544501687616108,"score_gpt":0.3523602432414032,"score_spread":0.2869152263652421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}