{"id":"W3092023810","doi":"10.1038/s41398-020-01013-y","title":"Structural neuroimaging biomarkers for obsessive-compulsive disorder in the ENIGMA-OCD consortium: medication matters","year":2020,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Obsessive-Compulsive Spectrum Disorders","field":"Psychology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Mental Health & Substance Use Services; McMaster University; St. Joseph’s Healthcare Hamilton; Hospital for Sick Children; University of British Columbia; University of Calgary; BC Children's Hospital; St Joseph's Health Care; University of Toronto; Centre for Addiction and Mental Health","funders":"National Center for Advancing Translational Sciences; National Institute of Biomedical Imaging and Bioengineering; National Institute of Mental Health; Japan Society for the Promotion of Science; Hartmann Müller-Stiftung für Medizinische Forschung; Canadian Institutes of Health Research; National Institutes of Health; National Research Foundation; Agència de Gestió d'Ajuts Universitaris i de Recerca; Alberta Innovates; The Wellcome Trust DBT India Alliance; Fundació la Marató de TV3; Medical Research Council; Hersenstichting; National Natural Science Foundation of China-Yunnan Joint Fund; Norges Forskningsråd; Ministry of Education, Culture, Sports, Science and Technology; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; European Regional Development Fund; Fundação para a Ciência e a Tecnologia; National Alliance for Research on Schizophrenia and Depression; ZonMw; National Health and Medical Research Council; Fundação de Amparo à Pesquisa do Estado de São Paulo; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Jacobs Foundation; Japan Agency for Medical Research and Development; Instituto de Salud Carlos III; National Natural Science Foundation of China; National Science Foundation; Massachusetts General Hospital; Department of Biotechnology, Ministry of Science and Technology, India; Helse Vest; Generalitat de Catalunya; Dana Foundation; Department of Science and Technology, Ministry of Science and Technology, India; Ministero della Salute; International OCD Foundation; Michael Smith Health Research BC; Wellcome; National Institute on Drug Abuse; South London and Maudsley NHS Foundation Trust; Ontario Brain Institute; Brain and Behavior Research Foundation; Provincial Health Services Authority; Wellcome Trust; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; U.S. Department of Health and Human Services","keywords":"Neuroimaging; Schizophrenia (object-oriented programming); Obsessive compulsive; Psychiatry; Psychology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000199365,0.0003393497,0.0003075245,0.0001642431,0.0002387773,0.0000607788,0.0006200767,0.0001198115,0.0008347097],"category_scores_gemma":[0.00004048316,0.0002906914,0.0002356513,0.0005616987,0.0002756629,0.0002211514,0.00001537442,0.0003897993,0.00008605646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002062448,"about_ca_system_score_gemma":0.0001333142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009404257,"about_ca_topic_score_gemma":0.0001576531,"domain_scores_codex":[0.9974211,0.0003045987,0.0006309425,0.000709363,0.0004337914,0.0005001673],"domain_scores_gemma":[0.9986966,0.0005333343,0.0002596728,0.0003242705,0.00006350148,0.0001226415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001765038,0.0003791651,0.8087557,0.0002253246,0.0006046848,0.00001942061,0.02619454,0.002540634,0.0004607236,0.1075616,0.03976408,0.01172907],"study_design_scores_gemma":[0.005744911,0.0001282757,0.9594721,0.00003035276,0.0001098897,0.00002550413,0.007119558,0.005548935,0.000003992838,0.01749944,0.003828407,0.0004886409],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.454373,0.002202027,0.02264468,0.511706,0.00315384,0.002339997,0.0002237329,0.0001665222,0.003190189],"genre_scores_gemma":[0.9771869,0.000006890575,0.002627442,0.0191704,0.0003978476,0.0001710064,0.0003654896,0.00005826451,0.0000157885],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.5228139,"threshold_uncertainty_score":0.9999545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02075488068257235,"score_gpt":0.3046204979812949,"score_spread":0.2838656172987225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}