{"id":"W3092023810","doi":"10.1038/s41398-020-01013-y","title":"Structural neuroimaging biomarkers for obsessive-compulsive disorder in the ENIGMA-OCD consortium: medication matters","year":2020,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Obsessive-Compulsive Spectrum Disorders","field":"Psychology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Mental Health & Substance Use Services; McMaster University; St. Joseph’s Healthcare Hamilton; Hospital for Sick Children; University of British Columbia; University of Calgary; BC Children's Hospital; St Joseph's Health Care; University of Toronto; Centre for Addiction and Mental Health","funders":"National Center for Advancing Translational Sciences; National Institute of Biomedical Imaging and Bioengineering; National Institute of Mental Health; Japan Society for the Promotion of Science; Hartmann Müller-Stiftung für Medizinische Forschung; Canadian Institutes of Health Research; National Institutes of Health; National Research Foundation; Agència de Gestió d'Ajuts Universitaris i de Recerca; Alberta Innovates; The Wellcome Trust DBT India Alliance; Fundació la Marató de TV3; Medical Research Council; Hersenstichting; National Natural Science Foundation of China-Yunnan Joint Fund; Norges Forskningsråd; Ministry of Education, Culture, Sports, Science and Technology; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; European Regional Development Fund; Fundação para a Ciência e a Tecnologia; National Alliance for Research on Schizophrenia and Depression; ZonMw; National Health and Medical Research Council; Fundação de Amparo à Pesquisa do Estado de São Paulo; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Jacobs Foundation; Japan Agency for Medical Research and Development; Instituto de Salud Carlos III; National Natural Science Foundation of China; National Science Foundation; Massachusetts General Hospital; Department of Biotechnology, Ministry of Science and Technology, India; Helse Vest; Generalitat de Catalunya; Dana Foundation; Department of Science and Technology, Ministry of Science and Technology, India; Ministero della Salute; International OCD Foundation; Michael Smith Health Research BC; Wellcome; National Institute on Drug Abuse; South London and Maudsley NHS Foundation Trust; Ontario Brain Institute; Brain and Behavior Research Foundation; Provincial Health Services Authority; Wellcome Trust; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; U.S. Department of Health and Human Services","keywords":"Neuroimaging; Schizophrenia (object-oriented programming); Obsessive compulsive; Psychiatry; Psychology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003563042,0.0007103659,0.0008862477,0.002320916,0.0006381974,0.001779801,0.0009407444,0.0008341793,0.001052566],"category_scores_gemma":[0.01324379,0.0003131808,0.0006952351,0.002204578,0.0007057209,0.0006761328,0.001700898,0.0006403399,0.0002479351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005052848,"about_ca_system_score_gemma":0.0004909121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006752891,"about_ca_topic_score_gemma":0.009935031,"domain_scores_codex":[0.99791,0.0007526773,0.0003103084,0.0004668136,0.0004071174,0.0001531269],"domain_scores_gemma":[0.9944966,0.001269302,0.002259168,0.0007842354,0.0008471055,0.0003436382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005349446,0.00005403295,0.9846532,0.00008357669,0.0008345129,0.0002319846,0.0002066518,0.0004563801,0.001679098,0.000117631,0.00068405,0.01046386],"study_design_scores_gemma":[0.0000469684,0.00008769531,0.9956725,0.0000435221,0.0002555744,0.0009772485,0.0001966416,0.0005516722,0.000699675,0.0002687738,0.001182818,0.00001697854],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958271,0.001005502,0.0006244138,0.0002578593,0.00001510787,0.00002693012,0.001686115,0.00001686168,0.0005401568],"genre_scores_gemma":[0.9947835,0.0002725531,0.0008092423,0.0001161992,0.00002576987,0.00004438529,0.003702955,0.0000172388,0.0002282119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006752891,"threshold_uncertainty_score":0.01884341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02075488068257235,"score_gpt":0.3046204979812949,"score_spread":0.2838656172987225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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