{"id":"W3092025944","doi":"10.1101/2020.10.09.333278","title":"Major role of IgM in the neutralizing activity of convalescent plasma against SARS-CoV-2","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; Western University; Université de Montréal; Robarts Clinical Trials; Héma-Québec; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; Fondation du CHUM","keywords":"Antibody; Neutralization; Isotype; Convalescent plasma; Immunology; Coronavirus disease 2019 (COVID-19); Neutralizing antibody; Virology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Immunoglobulin G; Medicine; Virus; Immunoglobulin M; Monoclonal antibody; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004498938,0.0003418605,0.0003253434,0.0004418269,0.0002194571,0.0004389466,0.0002502848,0.0002930676,0.001828253],"category_scores_gemma":[0.0006212895,0.00008939298,0.0001813078,0.0001399798,0.000213091,0.0001434191,0.0002678066,0.0003708671,0.0003228961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001912357,"about_ca_system_score_gemma":0.0002222637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007012091,"about_ca_topic_score_gemma":0.0003452147,"domain_scores_codex":[0.9997868,0.00007121662,0.00001729272,0.00003150856,0.00003829133,0.00005501368],"domain_scores_gemma":[0.9996339,0.00009819271,0.00006612886,0.00003364794,0.00008544386,0.00008262924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001977341,0.0002621092,0.04013828,0.00007192868,0.00005402624,0.0004120132,0.0001134854,0.0001234267,0.9416084,0.0001570307,0.0002509088,0.01483103],"study_design_scores_gemma":[0.000293525,0.006008051,0.4397219,0.00008199241,0.0002347479,0.004245293,0.0003625494,0.002013792,0.5389537,0.0003462685,0.007715958,0.00002216714],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968645,0.001065839,0.0006287819,0.00006384728,0.00001113487,0.00001999609,0.0001475055,0.00002422177,0.001174259],"genre_scores_gemma":[0.9985832,0.0001144676,0.0003526832,0.00007283688,0.00001302655,0.00001646912,0.0002530914,0.000006508071,0.0005877904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001828253,"threshold_uncertainty_score":0.006116092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0434463830626854,"score_gpt":0.2985565881611885,"score_spread":0.2551102050985031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}