{"id":"W3092041668","doi":"10.1016/j.mad.2020.111381","title":"Yeast MED2 is involved in the endoplasmic reticulum stress response and modulation of the replicative lifespan","year":2020,"lang":"en","type":"article","venue":"Mechanisms of Ageing and Development","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Aging","funders":"Guangdong Medical College; Natural Science Foundation of Guangdong Province; National Natural Science Foundation of China","keywords":"Endoplasmic reticulum; Tunicamycin; Unfolded protein response; Biology; Saccharomyces cerevisiae; Cell biology; Mediator; Transcription (linguistics); Transcription factor; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002273051,0.00009386781,0.0001131536,0.00001864493,0.00005514243,0.00001005937,0.0001231911,0.00005087754,0.000002542545],"category_scores_gemma":[0.0001534007,0.00006048718,0.00002523958,0.00006796232,0.0000631096,0.000003069651,0.0001287532,0.00005337933,2.363722e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003915067,"about_ca_system_score_gemma":0.0000630398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001922099,"about_ca_topic_score_gemma":0.00002065528,"domain_scores_codex":[0.9992173,0.0001175361,0.0002083758,0.000218124,0.0001430974,0.00009552977],"domain_scores_gemma":[0.9995928,0.00002686878,0.0001145563,0.0001820029,0.00003700154,0.00004677486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006381787,0.00007997359,0.01112717,0.0001659837,0.00005444768,0.000008115193,0.006425906,0.00009435337,0.9783927,0.0007756386,0.0001302522,0.002107289],"study_design_scores_gemma":[0.0004879534,0.00012338,0.09505585,0.00007374385,0.00001043138,0.000002303129,0.001730753,0.0003042145,0.9015697,0.000260981,0.0002903401,0.00009037587],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973724,0.0001510366,0.001339185,0.0008461737,0.00001771627,0.0001861256,0.00002125869,0.000002695216,0.00006340566],"genre_scores_gemma":[0.9984058,0.00005889777,0.001122517,0.000354179,0.000009037816,0.00001737532,0.00001090533,0.000006271767,0.00001499166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08392867,"threshold_uncertainty_score":0.2466595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01304277404622626,"score_gpt":0.2240920731402396,"score_spread":0.2110492990940133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}