{"id":"W3092077289","doi":"10.1128/mbio.02023-20","title":"Sensing Host Arginine Is Essential for <i>Leishmania</i> Parasites’ Intracellular Development","year":2020,"lang":"en","type":"article","venue":"mBio","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Phagolysosome; Leishmania; Arginine; Biology; Macrophage; Leishmania major; Immune system; Arginase; Intracellular parasite; Cell biology; Microbiology; Intracellular; Immunology; Phagosome; Parasite hosting; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001860316,0.0002759881,0.0002892993,0.0001218343,0.0002321351,0.0005921199,0.0002607313,0.0004298152,0.001637342],"category_scores_gemma":[0.0002577652,0.0001089058,0.0003182676,0.00009444045,0.0002895407,0.0003906213,0.0005132696,0.0006053656,0.000809034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002411224,"about_ca_system_score_gemma":0.0002719704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000440663,"about_ca_topic_score_gemma":0.0004625952,"domain_scores_codex":[0.9997543,0.00004010728,0.00002119686,0.00006044709,0.0000699208,0.00005399181],"domain_scores_gemma":[0.9997428,0.00003434879,0.00008795554,0.00003517743,0.00003857123,0.00006107691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006575383,0.00001006678,0.0003071233,0.00003896258,0.000002564536,0.0001386932,0.00001639218,0.0000208965,0.9981035,0.000141265,0.00005877123,0.0010959],"study_design_scores_gemma":[0.00001309281,0.0002535339,0.0113141,0.00001675761,0.00001969408,0.001551675,0.00009937455,0.0006877906,0.9718186,0.0002072297,0.01400043,0.00001779456],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9672098,0.006756086,0.01560005,0.0009618542,0.0002329003,0.00005176231,0.0008606935,0.0004634756,0.007863392],"genre_scores_gemma":[0.992174,0.001155219,0.003782965,0.0001761037,0.00002270098,0.00001793259,0.000523928,0.00005583709,0.002091197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001637342,"threshold_uncertainty_score":0.005477428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03942392493958569,"score_gpt":0.3022958233929689,"score_spread":0.2628718984533832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}