{"id":"W3092119968","doi":"10.3390/molecules25194572","title":"ATP-Binding and Hydrolysis in Inflammasome Activation","year":2020,"lang":"en","type":"review","venue":"Molecules","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"NLRC4; Inflammasome; ATP hydrolysis; Innate immune system; Pyrin domain; Walker motifs; Nucleotide; Biology; NOD1; Cell biology; Effector; ATPase; Pattern recognition receptor; Biochemistry; Receptor; NOD2; Enzyme; Caspase 1; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008502283,0.0003176509,0.0006194912,0.0001509027,0.00004676891,0.00003959272,0.0001796682,0.0003425127,0.000008525505],"category_scores_gemma":[0.00009249582,0.0003034719,0.0002014502,0.0002143691,0.00004603571,0.000005224903,0.0001817787,0.0002061094,0.00002568724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002343635,"about_ca_system_score_gemma":0.00009372153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008231248,"about_ca_topic_score_gemma":0.000005457665,"domain_scores_codex":[0.998777,0.00008719102,0.0003605399,0.0004502796,0.00009404463,0.0002309331],"domain_scores_gemma":[0.9995114,0.00001357762,0.000164966,0.0002454075,0.00001654991,0.0000481507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001599322,0.00001976049,0.00004190916,0.002197587,0.0001772104,0.00001924091,0.0001023118,0.000003940023,0.008109149,0.00003674995,0.0001405277,0.9891356],"study_design_scores_gemma":[0.0001994441,0.00005862373,0.00001960846,0.0008223873,0.00009136811,0.000008105102,0.00002465821,0.000007479351,0.001701671,0.000009434597,0.996726,0.0003311785],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006021273,0.9928073,0.00003737225,0.00005931421,0.00004125871,0.0003203598,0.000009811817,0.00001194079,0.0006913521],"genre_scores_gemma":[0.0007776443,0.9981088,0.00007685741,0.00007105696,0.00009122606,0.00007575406,0.0005884787,0.00005409256,0.0001560863],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9965855,"threshold_uncertainty_score":0.9999418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01370510665663426,"score_gpt":0.266293793976334,"score_spread":0.2525886873196997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}