{"id":"W3092119968","doi":"10.3390/molecules25194572","title":"ATP-Binding and Hydrolysis in Inflammasome Activation","year":2020,"lang":"en","type":"review","venue":"Molecules","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"NLRC4; Inflammasome; ATP hydrolysis; Innate immune system; Pyrin domain; Walker motifs; Nucleotide; Biology; NOD1; Cell biology; Effector; ATPase; Pattern recognition receptor; Biochemistry; Receptor; NOD2; Enzyme; Caspase 1; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002995829,0.0008747682,0.000830394,0.001758947,0.0002887096,0.0008454041,0.0006373079,0.001161754,0.002876847],"category_scores_gemma":[0.0003483956,0.0002342606,0.0003085942,0.001905495,0.0005135615,0.001311745,0.0007385799,0.00144176,0.002484418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005677117,"about_ca_system_score_gemma":0.0008201044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006071844,"about_ca_topic_score_gemma":0.0007938562,"domain_scores_codex":[0.9998981,0.00001675844,0.0000150402,0.00002222068,0.00003520586,0.00001272683],"domain_scores_gemma":[0.9998879,0.0000483032,0.00001899022,0.000003674116,0.00002607403,0.00001499635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009127575,0.00006359568,0.0001362865,0.01416567,0.0000478952,0.000266833,0.00006806995,0.0005087832,0.002191964,0.007444216,0.02767267,0.9473427],"study_design_scores_gemma":[0.00001460775,0.00008029587,0.0006924939,0.002640193,0.00004569283,0.001541065,0.00004937832,0.0001165939,0.0005041838,0.003697613,0.9906014,0.0000165589],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009224585,0.9985511,0.0000909936,0.0001878493,0.0002043085,0.000002045486,0.000007270229,0.000005626641,0.0008586532],"genre_scores_gemma":[0.0006125681,0.9985097,0.0000918938,0.0001261568,0.0001685993,0.00000422684,0.00001328758,9.316784e-7,0.0004725166],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002876847,"threshold_uncertainty_score":0.009624004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01370510665663426,"score_gpt":0.266293793976334,"score_spread":0.2525886873196997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}