{"id":"W3092140209","doi":"10.1016/j.ccell.2020.09.009","title":"Dual Checkpoint Blockade in Metastatic Castration-Resistant Prostate Cancer: Just a Gambit or Real CheckMate?","year":2020,"lang":"en","type":"letter","venue":"Cancer Cell","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Pfizer Canada; AstraZeneca Canada","keywords":"Gambit; Blockade; Prostate cancer; Medicine; Cancer research; Dual (grammatical number); Oncology; Cancer; Internal medicine; Computer science; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001790273,0.0008299093,0.001409669,0.0002505945,0.0001338505,0.0001205147,0.0002703039,0.000438354,0.003122446],"category_scores_gemma":[0.00003108146,0.0006174171,0.0002926398,0.0006978616,0.0002511363,0.0001551787,0.000125862,0.002321691,0.0001063545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002729842,"about_ca_system_score_gemma":0.005190712,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01509712,"about_ca_topic_score_gemma":0.005894298,"domain_scores_codex":[0.9952604,0.0001559607,0.0009824876,0.00123663,0.00107668,0.001287827],"domain_scores_gemma":[0.9982475,0.0001045652,0.000393486,0.0006054368,0.0002563919,0.0003925978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0052815,0.0003086123,0.0009515222,0.01019199,0.0007810216,0.03585514,0.003734858,0.00003813708,0.02814797,0.000001676584,0.9126649,0.002042688],"study_design_scores_gemma":[0.01556289,0.001710174,0.001291941,0.002904671,0.001930538,0.0001157067,0.001313847,0.0003199691,0.0614996,0.00004636068,0.9117595,0.001544822],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.05398422,0.02605554,0.000001984659,0.9008325,0.001280373,0.006098434,0.003391514,0.0002788343,0.008076565],"genre_scores_gemma":[0.06740289,0.1739022,0.001094016,0.3842011,0.01735669,0.0145015,0.008621908,0.001275447,0.3316441],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.5166314,"threshold_uncertainty_score":0.99998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0787338536318727,"score_gpt":0.3547603991219523,"score_spread":0.2760265454900797,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}