{"id":"W3092141337","doi":"10.1016/j.intimp.2020.107026","title":"Discovery of novel immunopharmacological ligands targeting the IL-17 inflammatory pathway","year":2020,"lang":"en","type":"article","venue":"International Immunopharmacology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Xunta de Galicia; Innovative Medicines Initiative; Debreceni Egyetem; Ministero dello Sviluppo Economico; Ministerio de Ciencia e Innovación; Ministerio de Economía y Competitividad; Novartis Pharma; Canada Foundation for Innovation; Ontario Ministry of Economic Development and Innovation; Ministerio de Ciencia, Innovación y Universidades; Wellcome Trust; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Boehringer Ingelheim; Janssen Pharmaceuticals; Merck KGaA; European Regional Development Fund; Meso Scale Diagnostics; AbbVie; Takeda Pharmaceutical Company; Pfizer","keywords":"Proinflammatory cytokine; Chemokine; Chemistry; Cytokine; Interleukin 17; Pharmacology; Drug discovery; Virtual screening; Immunology; Inflammation; Biology; Biochemistry; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001796103,0.0003270008,0.0002556391,0.0002329965,0.0001497157,0.0005190923,0.0002538101,0.0002702441,0.002575013],"category_scores_gemma":[0.0001198176,0.000106705,0.000238351,0.0001202478,0.0002252722,0.0002464071,0.0003092097,0.000879109,0.0004760476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002565239,"about_ca_system_score_gemma":0.0002986487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001244505,"about_ca_topic_score_gemma":0.0002856252,"domain_scores_codex":[0.9999409,0.00001076125,0.000002335886,0.00000741883,0.00001468246,0.0000238444],"domain_scores_gemma":[0.999954,0.00000648609,0.00001067688,0.000003010943,0.00000797278,0.00001774669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009661419,0.0005752987,0.000841952,0.0004816102,0.00005372793,0.0006146497,0.00008700278,0.001419818,0.8531066,0.006994568,0.002940389,0.1319183],"study_design_scores_gemma":[0.0008390973,0.004688402,0.004212258,0.0002121873,0.0001587151,0.002740216,0.0001817317,0.004756531,0.8485336,0.003290022,0.1303359,0.00005133576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8704437,0.0612849,0.04081378,0.003104574,0.0008007359,0.0004158628,0.0005599844,0.0003610774,0.02221538],"genre_scores_gemma":[0.9527476,0.02178462,0.01364309,0.0009358012,0.000189018,0.0002131969,0.0005087407,0.00003045745,0.009947512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002575013,"threshold_uncertainty_score":0.008614242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02488114799132078,"score_gpt":0.2705651862935972,"score_spread":0.2456840383022764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}