{"id":"W3092165478","doi":"10.1158/1557-3125.pi3k-mtor18-a20","title":"Abstract A20: Investigating the role of SCO2 in the metabolic adaptation of cancer cells","year":2020,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Citric acid cycle; Oxidative phosphorylation; Mitochondrion; Glycolysis; Cancer cell; Nicotinamide adenine dinucleotide; Biochemistry; Metabolism; Biology; Reactive oxygen species; Oxidase test; Chemistry; NAD+ kinase; Cancer; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001005703,0.0002590421,0.0002197065,0.0002397568,0.0002248198,0.0003211192,0.0001798888,0.0003389011,0.001592821],"category_scores_gemma":[0.00009787506,0.00006209021,0.0001972745,0.0005026277,0.0001466837,0.0002258552,0.0001718466,0.0003155554,0.0004715812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002965635,"about_ca_system_score_gemma":0.0002231562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001166031,"about_ca_topic_score_gemma":0.001040596,"domain_scores_codex":[0.9999199,0.000006567894,0.000004179716,0.00002397108,0.00002898872,0.00001644549],"domain_scores_gemma":[0.9999207,0.000008192848,0.00001669486,0.00000634321,0.00002336754,0.00002466311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000155978,0.00001626994,0.0007163844,0.0000538948,0.000006091111,0.00005257909,0.00001224505,0.00005260466,0.9976399,0.0000473477,0.0000912945,0.00115539],"study_design_scores_gemma":[0.00001732978,0.0003716601,0.02013184,0.00001236145,0.00002280352,0.0002502238,0.00009488753,0.001469536,0.9692473,0.0001360682,0.008238071,0.000007906937],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858759,0.004391362,0.003849014,0.0003296108,0.0001038593,0.00006381691,0.003081877,0.00009997559,0.002204662],"genre_scores_gemma":[0.9871531,0.002164809,0.002519495,0.0001668346,0.0000247442,0.0000634207,0.004100589,0.00003140259,0.00377552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001592821,"threshold_uncertainty_score":0.005328476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06777723019468028,"score_gpt":0.3587593269293501,"score_spread":0.2909820967346698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}