{"id":"W3092218036","doi":"10.1111/acel.13245","title":"Blood extracellular vesicles from healthy individuals regulate hematopoietic stem cells as humans age","year":2020,"lang":"en","type":"article","venue":"Aging Cell","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Université de Montréal; Kingston Health Sciences Centre; Institute for Research in Immunology and Cancer; Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Extracellular vesicles; Haematopoiesis; Stem cell; Cell biology; Vesicle; Extracellular; Extracellular vesicle; Hematopoietic stem cell; Immunology; Microvesicles; Physiology; Genetics; Gene; Membrane; microRNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002254559,0.0003831038,0.0003324084,0.00004194985,0.0001778891,0.000110998,0.0006460836,0.0002321205,0.000143879],"category_scores_gemma":[0.00001810962,0.0004268395,0.0002184944,0.0001483304,0.0001386425,0.00001161837,0.0003330051,0.0002578632,0.00034679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001482962,"about_ca_system_score_gemma":0.0001092275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004265061,"about_ca_topic_score_gemma":0.000004202524,"domain_scores_codex":[0.9974039,0.0002032721,0.0005130556,0.0009602162,0.0003494629,0.0005701508],"domain_scores_gemma":[0.9983214,0.00004055372,0.0002383072,0.0008478125,0.00004440285,0.0005075358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004137347,0.0002094902,0.001465134,0.0001309975,0.00008769475,0.0002854771,0.0009931034,0.00009726433,0.9936437,0.00007378243,0.00258093,0.0003910433],"study_design_scores_gemma":[0.00115099,0.0002622519,0.0002290624,0.00003649557,0.0001610061,0.000006238124,0.0003656671,0.00005156322,0.9726403,0.0003862934,0.02421804,0.0004921349],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823522,0.01462939,0.0006833049,0.0006886015,0.0001680421,0.0003573764,0.00007694038,0.0001039883,0.0009401362],"genre_scores_gemma":[0.9938407,0.0002594262,0.001472184,0.002090063,0.0004964827,0.00001841192,0.0002260955,0.0001121187,0.001484521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0216371,"threshold_uncertainty_score":0.9998183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01411172269499239,"score_gpt":0.2369300963585596,"score_spread":0.2228183736635672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}