{"id":"W3092218036","doi":"10.1111/acel.13245","title":"Blood extracellular vesicles from healthy individuals regulate hematopoietic stem cells as humans age","year":2020,"lang":"en","type":"article","venue":"Aging Cell","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Université de Montréal; Kingston Health Sciences Centre; Institute for Research in Immunology and Cancer; Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Extracellular vesicles; Haematopoiesis; Stem cell; Cell biology; Vesicle; Extracellular; Extracellular vesicle; Hematopoietic stem cell; Immunology; Microvesicles; Physiology; Genetics; Gene; Membrane; microRNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003130838,0.0002726132,0.0003347049,0.0003713127,0.0001930542,0.0006326085,0.000114491,0.0002929497,0.0009969415],"category_scores_gemma":[0.0007115747,0.0001313769,0.0002358067,0.0002164988,0.0001886049,0.0003994674,0.000533921,0.0002710163,0.0003366953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001741048,"about_ca_system_score_gemma":0.0001596582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005216982,"about_ca_topic_score_gemma":0.0005492077,"domain_scores_codex":[0.9997974,0.0000476022,0.00001678706,0.00005747379,0.00005175544,0.00002897876],"domain_scores_gemma":[0.9997918,0.00004651618,0.00008098451,0.0000151226,0.00004199005,0.00002367624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009259548,0.00006784596,0.04309512,0.000244138,0.0000879269,0.0003941552,0.000394314,0.0007768634,0.886687,0.0012948,0.001147636,0.06488429],"study_design_scores_gemma":[0.00005364086,0.0008239903,0.4169614,0.0002112704,0.0002156244,0.00289498,0.0008486941,0.006978668,0.5359766,0.003914999,0.03105821,0.00006195418],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816217,0.009054422,0.005998264,0.0002510766,0.00005396641,0.00002592252,0.0009427638,0.0001076412,0.001944257],"genre_scores_gemma":[0.992915,0.002125869,0.002978147,0.0001538247,0.00002176656,0.00002436331,0.0006405488,0.00003045666,0.001110057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009969415,"threshold_uncertainty_score":0.003335118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01411172269499239,"score_gpt":0.2369300963585596,"score_spread":0.2228183736635672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}