{"id":"W3092222387","doi":"10.1136/annrheumdis-2020-218992","title":"Age-based (<65 vs ≥65 years) incidence of infections and serious infections with tofacitinib versus biological DMARDs in rheumatoid arthritis clinical trials and the US Corrona RA registry","year":2020,"lang":"en","type":"letter","venue":"Annals of the Rheumatic Diseases","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pfizer (Canada)","funders":"Pfizer","keywords":"Tofacitinib; Medicine; Rheumatoid arthritis; Internal medicine; Etanercept; Adalimumab; Incidence (geometry); Tocilizumab; Janus kinase inhibitor; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch","metaepi_broad"],"consensus_categories":[],"category_scores_codex":[0.01583102,0.0004291439,0.00113685,0.0010279,0.0003290125,0.001485859,0.0007161137,0.0006600161,0.004949127],"category_scores_gemma":[0.01827937,0.0003319792,0.003678752,0.001642973,0.0002410406,0.001121665,0.0009770776,0.001055137,0.001011295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004318538,"about_ca_system_score_gemma":0.001228247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001851265,"about_ca_topic_score_gemma":0.005483618,"domain_scores_codex":[0.9899187,0.005230372,0.002264506,0.0009124103,0.001317567,0.000356343],"domain_scores_gemma":[0.9793941,0.004726046,0.01109411,0.001616708,0.002231304,0.0009377525],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.236478,0.000779168,0.519358,0.009228268,0.02373637,0.0003312149,0.0004944439,0.001423732,0.002262168,0.002452878,0.04856159,0.1548941],"study_design_scores_gemma":[0.03116287,0.007083318,0.898488,0.001462409,0.01277131,0.0008345599,0.0002058584,0.001090192,0.001360526,0.001120111,0.04429707,0.0001237542],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7757512,0.06206585,0.00798301,0.003074296,0.001402668,0.007786005,0.1028137,0.0004235342,0.03869973],"genre_scores_gemma":[0.9393592,0.008347342,0.00534775,0.002009312,0.0009210294,0.004601506,0.03278952,0.00008209456,0.006542189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9988632,"threshold_uncertainty_score":0.08372343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0900191227390695,"score_gpt":0.3719142506461895,"score_spread":0.28189512790712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}