{"id":"W3092223474","doi":"10.1016/j.ejmech.2020.112902","title":"SP1-independent inhibition of FOXM1 by modified thiazolidinediones","year":2020,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta","keywords":"Chemistry; Thiazolidinedione; Troglitazone; Reporter gene; FOXM1; Electrophoretic mobility shift assay; In vitro; Ligand binding assay; Pioglitazone; Transcription factor; Biochemistry; Pharmacology; Gene expression; Peroxisome proliferator-activated receptor; Receptor; Gene; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003733178,0.00012378,0.0001790708,0.0000169123,0.00002368618,0.000007592267,0.0001677041,0.00005269577,0.00007610783],"category_scores_gemma":[0.0001354592,0.0001101679,0.0001220787,0.00006205665,0.0000778242,0.000008281795,0.0000294557,0.0001871684,0.000003912252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001146612,"about_ca_system_score_gemma":0.00004628182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":6.059263e-7,"about_ca_topic_score_gemma":6.328999e-8,"domain_scores_codex":[0.9987895,0.0000866573,0.0004962489,0.0001470905,0.0003710185,0.0001094315],"domain_scores_gemma":[0.9991155,0.000006457697,0.0003973542,0.000115106,0.0001853,0.0001802332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003068639,0.00004008013,0.0001554109,0.00008037371,0.00004308176,0.00002978381,0.0001111829,0.0001217461,0.9902248,0.000003292884,0.008063397,0.0008199346],"study_design_scores_gemma":[0.001491862,0.0005372828,0.0008134173,0.00007501022,0.00004199646,0.0001040829,0.0001686841,0.00003828681,0.9892613,0.000007715615,0.007355915,0.0001044111],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863446,0.0009266749,0.008481792,0.001217666,0.0001025157,0.00004197812,0.00001465329,0.000006050135,0.002864095],"genre_scores_gemma":[0.9986228,0.0001176975,0.0001536039,0.0002259812,0.0006937115,2.429058e-7,0.00006059186,0.00002056905,0.0001047546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01227827,"threshold_uncertainty_score":0.4492518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0154233924911126,"score_gpt":0.2162926543906487,"score_spread":0.2008692618995361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}