{"id":"W3092226358","doi":"10.1158/2326-6066.cir-20-0527","title":"The Prognostic Role of Macrophage Polarization in the Colorectal Cancer Microenvironment","year":2020,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":236,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Gary Bennett Family Fund; Suomen Kulttuurirahasto; Stand Up To Cancer; Uehara Memorial Foundation; National Institutes of Health; Orionin Tutkimussäätiö; American Institute for Cancer Research; National Cancer Institute; Entertainment Industry Foundation; Mitsukoshi Health and Welfare Foundation; American Association for Cancer Research; American Society of Clinical Oncology; Japan Society for the Promotion of Science; Cancer Research UK; Conquer Cancer Foundation","keywords":"Tumor microenvironment; Colorectal cancer; Medicine; Cancer research; Macrophage polarization; Cancer; Macrophage; Immunology; Oncology; Immune system; Internal medicine; Biology; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009070552,0.0001490515,0.0002176486,0.0006223571,0.0001831473,0.0003465431,0.000117307,0.000220318,0.0004557419],"category_scores_gemma":[0.001297442,0.000116552,0.0001219584,0.0004178725,0.0002088479,0.0001973417,0.0002594032,0.0002309242,0.0001187602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001513245,"about_ca_system_score_gemma":0.00009687456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003651515,"about_ca_topic_score_gemma":0.0007768765,"domain_scores_codex":[0.9997324,0.0001253902,0.00001490041,0.00004422328,0.0000386058,0.00004438037],"domain_scores_gemma":[0.9992915,0.0002670847,0.0002024998,0.00007735413,0.00008137277,0.00008008638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000770235,0.0000251764,0.9474059,0.00002389731,0.0000453994,0.00007847022,0.00005076778,0.0004732182,0.0376148,0.00004896502,0.00004985826,0.01341328],"study_design_scores_gemma":[0.000009221095,0.0002465493,0.9766174,0.000007869759,0.0000654567,0.0007691387,0.0001425806,0.005004237,0.01652623,0.0001935547,0.0004054124,0.00001238833],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986789,0.0004083643,0.0007355636,0.00001369995,0.000001475709,0.000003371174,0.00004405862,0.000007058683,0.0001075246],"genre_scores_gemma":[0.9994647,0.00006560333,0.0003808214,0.000003349989,0.000001944294,0.000002733425,0.00003316938,0.000001090082,0.00004662326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009070552,"threshold_uncertainty_score":0.004796982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02744763062954976,"score_gpt":0.3126443706912673,"score_spread":0.2851967400617176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}