{"id":"W3092226358","doi":"10.1158/2326-6066.cir-20-0527","title":"The Prognostic Role of Macrophage Polarization in the Colorectal Cancer Microenvironment","year":2020,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":236,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Gary Bennett Family Fund; Suomen Kulttuurirahasto; Stand Up To Cancer; Uehara Memorial Foundation; National Institutes of Health; Orionin Tutkimussäätiö; American Institute for Cancer Research; National Cancer Institute; Entertainment Industry Foundation; Mitsukoshi Health and Welfare Foundation; American Association for Cancer Research; American Society of Clinical Oncology; Japan Society for the Promotion of Science; Cancer Research UK; Conquer Cancer Foundation","keywords":"Tumor microenvironment; Colorectal cancer; Medicine; Cancer research; Macrophage polarization; Cancer; Macrophage; Immunology; Oncology; Immune system; Internal medicine; Biology; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001054984,0.0001790056,0.0002733726,0.00009301484,0.000508752,0.00002552748,0.001249369,0.0002876003,0.000700528],"category_scores_gemma":[0.0003010075,0.0001154183,0.00007452734,0.000655435,0.002052302,0.000063214,0.0003822838,0.001480667,0.0001985151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002439813,"about_ca_system_score_gemma":0.0003445524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001167341,"about_ca_topic_score_gemma":0.0002686616,"domain_scores_codex":[0.996743,0.001497411,0.0004231299,0.0003848563,0.0001452923,0.0008062891],"domain_scores_gemma":[0.9984112,0.000902248,0.000136646,0.0003923547,0.0001401318,0.00001740339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006640929,0.00008056112,0.05318964,0.00002264002,0.0001902868,0.000004975265,0.003678627,0.00002978401,0.9251276,0.0004339312,0.001387279,0.01519061],"study_design_scores_gemma":[0.001646025,0.0005371337,0.2504882,0.00006918133,0.00003744504,0.00001948617,0.004793204,0.0000331423,0.6158292,0.0002290532,0.1261126,0.0002054124],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8123021,0.179289,0.000005948219,0.006540781,0.0004826336,0.000880755,0.00004541193,0.00001636504,0.0004370202],"genre_scores_gemma":[0.9889821,0.009141236,0.000006125691,0.0002758545,0.00005908382,0.0008700974,0.0000271758,0.00002705391,0.0006112643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3092984,"threshold_uncertainty_score":0.7670291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02744763062954976,"score_gpt":0.3126443706912673,"score_spread":0.2851967400617176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}