{"id":"W3092249496","doi":"10.21577/0103-5053.20200202","title":"Synthesis and Biological Evaluation of Benzo[f]indole-4,9-diones N-Linked to Carbohydrate Chains as New Type of Antitumor Agents","year":2020,"lang":"en","type":"article","venue":"Journal of the Brazilian Chemical Society","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Air (Canada)","funders":"Fundação Oswaldo Cruz; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Indole test; Chemistry; Carbohydrate; Combinatorial chemistry; Stereochemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006265024,0.0001989005,0.0001062522,0.0001474659,0.00007198056,0.0001182951,0.0001482808,0.0001000036,0.0006804901],"category_scores_gemma":[0.00008584988,0.00004796751,0.0001044161,0.0001513002,0.00008819377,0.0001269638,0.00007839115,0.0001572096,0.0001612928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001310298,"about_ca_system_score_gemma":0.0001541355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003949514,"about_ca_topic_score_gemma":0.001027863,"domain_scores_codex":[0.9999698,0.000006428148,0.00000225245,0.000005234826,0.000008379081,0.000007842877],"domain_scores_gemma":[0.9999546,0.000005478313,0.00001289743,0.000004226672,0.00001064508,0.00001222067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009772411,0.00005733515,0.0003040391,0.0001600039,0.000006909072,0.0001513494,0.00002374524,0.0003645153,0.9921897,0.0002031461,0.00004088147,0.006400659],"study_design_scores_gemma":[0.00003115104,0.00157146,0.003880457,0.00002365021,0.00003484175,0.0003069768,0.0000309498,0.0003764997,0.9845662,0.00007790318,0.00908976,0.00001026454],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847679,0.007397386,0.003885392,0.00007688447,0.00004272431,0.00009235293,0.0003188819,0.00003292891,0.003385502],"genre_scores_gemma":[0.9879892,0.004060886,0.005553635,0.00003804187,0.00001428957,0.00003587115,0.0002831121,0.000007190484,0.002017841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006804901,"threshold_uncertainty_score":0.002276421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2601216018620365,"score_gpt":0.4414256967134327,"score_spread":0.1813040948513962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}