{"id":"W3092254257","doi":"10.1002/ijc.33338","title":"Circulating adipokine concentrations and risk of five obesity‐related cancers: A Mendelian randomization study","year":2020,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute of Environmental Health Sciences; National Institute on Aging; Instituto de Salud Carlos III; National Institute for Health and Care Research; Agència de Gestió d'Ajuts Universitaris i de Recerca; Ontario Ministry of Research and Innovation; National Health and Medical Research Council; National Institute of Diabetes and Digestive and Kidney Diseases; World Cancer Research Fund; Medical Research Council; U.S. Public Health Service; Centers for Disease Control and Prevention; Chonnam National University Hwasun Hospital; European Commission; Centre Hospitalier Universitaire de Nantes; Groupement des Entreprises Françaises dans la lutte contre le Cancer; Biobanco Vasco; Xunta de Galicia; National Human Genome Research Institute; Cancer Council Victoria; Deutsche Krebshilfe; NordForsk; Vetenskapsrådet; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Canadian Institutes of Health Research; Cancerfonden; Hellenic Health Foundation; National Cancer Institute; Fundación Científica Asociación Española Contra el Cáncer; Generalitat de Catalunya; Food Standards Agency; World Health Organization; Wageningen University and Research; Cancer Research UK; Chonnam National University; Centres de Recerca de Catalunya; Institut Gustave-Roussy; University of South Florida; Johns Hopkins University; Centre International de Recherche sur le Cancer; Deutsches Krebsforschungszentrum; Harvard T.H. Chan School of Public Health; Mike and Josie Harper Cancer Research Institute; National Institutes of Health; National Heart, Lung, and Blood Institute; Florida Department of Health; Conseil Régional des Pays de la Loire; University of Pittsburgh; Memorial Sloan-Kettering Cancer Center; Association Anne de Bretagne Genetique; Damon Runyon Cancer Research Foundation; U.S. Department of Health and Human Services; American Institute for Cancer Research; Brigham and Women's Hospital; Institut National de la Santé et de la Recherche Médicale","keywords":"Mendelian randomization; Adipokine; Obesity; Medicine; Oncology; Internal medicine; Endocrinology; Bioinformatics; Genetics; Biology; Gene; Leptin; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015946,0.00008140159,0.000186717,0.00004556861,0.00002791374,0.00001876481,0.0001321238,0.00004270437,0.0000568781],"category_scores_gemma":[0.0001729752,0.00007360133,0.00008062426,0.00006829247,0.0000415015,0.00001516447,0.00003325845,0.00009503554,2.68859e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003903616,"about_ca_system_score_gemma":0.0002286921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003565749,"about_ca_topic_score_gemma":0.0002725669,"domain_scores_codex":[0.9990968,0.0000698155,0.0004017471,0.000121704,0.0002378615,0.00007208336],"domain_scores_gemma":[0.9988029,0.00001748945,0.000509206,0.00005181617,0.000544039,0.0000745287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005366581,0.0003901407,0.405167,0.00004665323,0.009167159,0.000007070776,0.01178177,0.1177569,0.4119651,0.0002369923,0.01002812,0.02808651],"study_design_scores_gemma":[0.1567984,0.004120355,0.3611372,0.0008035267,0.005559612,0.0003366365,0.01367614,0.03401212,0.112899,0.0007787357,0.3080429,0.001835434],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891939,0.005230301,0.002149095,0.0004170095,0.002665224,0.000158713,0.00007346573,0.000002508299,0.0001097608],"genre_scores_gemma":[0.9914737,0.004256987,0.0001345339,0.0001655542,0.003908668,0.000004672509,0.00001138679,0.000008677817,0.00003584399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2990661,"threshold_uncertainty_score":0.3001375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008494550104106317,"score_gpt":0.2785131710726472,"score_spread":0.2700186209685409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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