{"id":"W3092264786","doi":"10.1038/s41467-020-18700-5","title":"Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Medical Research Council; National Institutes of Health; Canadian Institutes of Health Research; Sanming Project of Medicine in Shenzhen; National Health and Medical Research Council; Illawarra Health and Medical Research Institute; University of Wollongong; Wellcome Trust","keywords":"Streptococcus pyogenes; Prophage; Superantigen; Microbiology; Biology; Scarlet fever; Virulence; Bacteriophage; Genetics; Staphylococcus aureus; Bacteria; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001469803,0.0002148253,0.0002087153,0.000141452,0.00007515878,0.0002263264,0.0001174451,0.0001610171,0.0009564369],"category_scores_gemma":[0.0002303808,0.00009047776,0.0001266135,0.00008826377,0.0001482532,0.000134948,0.0002658166,0.0003666874,0.000111238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001217228,"about_ca_system_score_gemma":0.0001533704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002715051,"about_ca_topic_score_gemma":0.0004727631,"domain_scores_codex":[0.9998871,0.00002563554,0.000006572378,0.00001125832,0.00002528992,0.00004414315],"domain_scores_gemma":[0.9998444,0.00003880873,0.00003077081,0.00001190737,0.00001130683,0.00006274055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003605759,0.0001063812,0.001702374,0.00002548174,0.000004345668,0.00008992262,0.0000267331,0.00006417483,0.9953225,0.00004294526,0.0000277064,0.002226871],"study_design_scores_gemma":[0.00008676144,0.007357038,0.1226527,0.00001702293,0.00004409596,0.00125325,0.000294178,0.002335066,0.8642156,0.0002156904,0.001516437,0.00001213164],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994887,0.0001492047,0.000133382,0.0000167745,0.000002649011,0.000003377903,0.00001629058,0.000005212788,0.0001844459],"genre_scores_gemma":[0.9990464,0.0001317511,0.0002832617,0.00001216715,0.000003015063,0.000003905147,0.00004925106,0.000003467022,0.0004668299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009564369,"threshold_uncertainty_score":0.003199637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0471068615086902,"score_gpt":0.3617734109761868,"score_spread":0.3146665494674966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}