{"id":"W3092288248","doi":"10.1093/eurheartj/ehaa649","title":"Lipoprotein(a) lowering by alirocumab reduces the total burden of cardiovascular events independent of low-density lipoprotein cholesterol lowering: ODYSSEY OUTCOMES trial","year":2020,"lang":"en","type":"article","venue":"European Heart Journal","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":209,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian VIGOUR Centre; University of Alberta; St. Michael's Hospital","funders":"NIHR Imperial Biomedical Research Centre; American Regent; Genentech; Esperion Therapeutics; Sirtex Medical; HLS Therapeutics; Idorsia Pharmaceuticals; Novo Nordisk; Duke Clinical Research Institute; Astellas Pharma; Eisai; Daiichi-Sankyo; European Commission; Medicines Company; Regado Biosciences; Tenax Therapeutics; AstraZeneca; Amarin Corporation; Ionis Pharmaceuticals; Luitpold Pharmaceuticals; F. Hoffmann-La Roche; Ironwood Pharmaceuticals, Incorporated; Regeneron Pharmaceuticals; Boston VA Research Institute; Boston Scientific Corporation; Eli Lilly and Company; Cleveland Clinic; Bristol-Myers Squibb; National Institute for Health and Care Research; CSL Behring; Belvoir Media Group; Servier; Gilead Sciences; European Society of Cardiology; Amgen; Pfizer; St. Jude Medical; Kowa Company; National Institute of Diabetes and Digestive and Kidney Diseases; Sanofi; American Heart Association","keywords":"Medicine; Alirocumab; Ldl cholesterol; Cholesterol; Lipoprotein; Atherosclerotic cardiovascular disease; Lipoprotein(a); Internal medicine; Cardiology; Disease; Apolipoprotein A1","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003695103,0.0004236159,0.001487927,0.0001164904,0.0002667377,0.00006935714,0.0004640457,0.0001218423,0.0000862526],"category_scores_gemma":[0.0004997391,0.0002996282,0.002078055,0.0003034988,0.0001376199,0.0002022774,0.0003229514,0.001205369,0.00003911633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009939363,"about_ca_system_score_gemma":0.0002402059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000578457,"about_ca_topic_score_gemma":0.000001745332,"domain_scores_codex":[0.9944893,0.0007937646,0.001242609,0.0005305809,0.002374178,0.0005695567],"domain_scores_gemma":[0.9974801,0.0000426494,0.0005133392,0.00105918,0.0002920454,0.0006127114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.05907103,0.003677981,0.008502902,0.005674933,0.03789365,0.003476676,0.01892013,0.00870188,0.3858048,0.00002079251,0.009064574,0.4591907],"study_design_scores_gemma":[0.1585387,0.01184635,0.2642215,0.003911505,0.003531207,0.007232434,0.002717317,0.0002407943,0.5096404,0.00003291343,0.03599687,0.002090049],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906574,0.003182884,0.0008895497,0.002401966,0.0006368093,0.001767829,0.00001556137,0.00005372752,0.0003942362],"genre_scores_gemma":[0.9965012,0.0002860735,0.0001849445,0.0002663783,0.002486236,0.00001378843,0.000006351961,0.0001094099,0.0001456074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4571006,"threshold_uncertainty_score":0.9999456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02990753761901035,"score_gpt":0.2707455877341741,"score_spread":0.2408380501151638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}