{"id":"W3092288248","doi":"10.1093/eurheartj/ehaa649","title":"Lipoprotein(a) lowering by alirocumab reduces the total burden of cardiovascular events independent of low-density lipoprotein cholesterol lowering: ODYSSEY OUTCOMES trial","year":2020,"lang":"en","type":"article","venue":"European Heart Journal","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":209,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian VIGOUR Centre; University of Alberta; St. Michael's Hospital","funders":"NIHR Imperial Biomedical Research Centre; American Regent; Genentech; Esperion Therapeutics; Sirtex Medical; HLS Therapeutics; Idorsia Pharmaceuticals; Novo Nordisk; Duke Clinical Research Institute; Astellas Pharma; Eisai; Daiichi-Sankyo; European Commission; Medicines Company; Regado Biosciences; Tenax Therapeutics; AstraZeneca; Amarin Corporation; Ionis Pharmaceuticals; Luitpold Pharmaceuticals; F. Hoffmann-La Roche; Ironwood Pharmaceuticals, Incorporated; Regeneron Pharmaceuticals; Boston VA Research Institute; Boston Scientific Corporation; Eli Lilly and Company; Cleveland Clinic; Bristol-Myers Squibb; National Institute for Health and Care Research; CSL Behring; Belvoir Media Group; Servier; Gilead Sciences; European Society of Cardiology; Amgen; Pfizer; St. Jude Medical; Kowa Company; National Institute of Diabetes and Digestive and Kidney Diseases; Sanofi; American Heart Association","keywords":"Medicine; Alirocumab; Ldl cholesterol; Cholesterol; Lipoprotein; Atherosclerotic cardiovascular disease; Lipoprotein(a); Internal medicine; Cardiology; Disease; Apolipoprotein A1","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001306143,0.0007951258,0.00135904,0.0001726792,0.0002722994,0.0007346079,0.0003884749,0.0005704684,0.002689223],"category_scores_gemma":[0.001884971,0.0001925838,0.001149213,0.0001825331,0.0003718206,0.0004830155,0.0005183541,0.001408772,0.0001916521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003764717,"about_ca_system_score_gemma":0.0007379059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0018023,"about_ca_topic_score_gemma":0.003620469,"domain_scores_codex":[0.9995368,0.0002382296,0.00003808342,0.00007726811,0.0000583421,0.0000513087],"domain_scores_gemma":[0.9993396,0.0001273963,0.0002069769,0.00005656422,0.00007045945,0.0001990043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.903051,0.004436413,0.01590714,0.003017292,0.005828192,0.0001188882,0.0001272093,0.001109796,0.00492406,0.0005769649,0.005981112,0.05492187],"study_design_scores_gemma":[0.8119264,0.06155984,0.1041259,0.000422821,0.009391019,0.0003385163,0.00009675889,0.003981607,0.001695281,0.0007984399,0.005592571,0.0000707335],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842613,0.009222896,0.0004405273,0.0009950572,0.0001527099,0.0005275534,0.001693521,0.00008301774,0.002623389],"genre_scores_gemma":[0.9909932,0.0027955,0.0008874512,0.001024203,0.0002191217,0.0005654925,0.001709505,0.00001226975,0.001793149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002689223,"threshold_uncertainty_score":0.008996308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02990753761901035,"score_gpt":0.2707455877341741,"score_spread":0.2408380501151638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}