{"id":"W3092288940","doi":"10.1053/j.gastro.2020.09.043","title":"Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer","year":2020,"lang":"en","type":"article","venue":"Gastroenterology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":173,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cancer Council NSW; National Health and Medical Research Council; Engineering and Physical Sciences Research Council; Medical Research Council; National Institutes of Health; Queensland Government; Gastroenterological Society of Australia; Associazione Italiana per la Ricerca sul Cancro; University of Queensland; Royal Adelaide Hospital; Garvan Institute of Medical Research; Howat Foundation; Cancer Institute NSW; National Cancer Institute; Australian Cancer Research Foundation; Royal College of Surgeons of Edinburgh; University of Glasgow; Wellcome Trust; Cancer Research UK; Johns Hopkins University; Petre Foundation; Fondazione Italiana per la ricerca sulle Malattie del Pancreas; Pancreatic Cancer UK; Australian Government; Royal College of Physicians; University of California, San Francisco; Ministero della Salute; Ontario Institute for Cancer Research; Royal College of Pathologists of Australasia; R.T. Hall Trust; American Association for Cancer Research","keywords":"DNA damage; Replication (statistics); Pancreatic cancer; Cancer research; Fight-or-flight response; Medicine; Cancer; Oncology; DNA; Biology; Internal medicine; Genetics; Virology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001917908,0.00009385408,0.0001221982,0.00002531627,0.00002106664,0.000007284004,0.0001040116,0.00007123457,0.00001595889],"category_scores_gemma":[0.0001901901,0.00009887458,0.00002077393,0.0000373564,0.00004063908,0.000002997059,0.0001227496,0.00007114068,0.000002437185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000104422,"about_ca_system_score_gemma":0.00001569229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001763181,"about_ca_topic_score_gemma":0.00005798649,"domain_scores_codex":[0.9989948,0.0001933695,0.000157583,0.0003988249,0.00004405855,0.0002114253],"domain_scores_gemma":[0.9996178,0.000009585152,0.00006063024,0.0002206794,0.00001978318,0.00007151724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001308579,0.00001438109,0.1811467,0.00001165285,0.00001207499,0.000006563345,0.00008891836,0.00006631849,0.8169684,0.000005165798,0.0002483923,0.0001227684],"study_design_scores_gemma":[0.00291978,0.002961349,0.4070864,0.00003926167,0.00004016421,0.00003187665,0.0003985838,0.003770735,0.5790075,0.00005287023,0.00343182,0.0002596949],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966871,0.0001351887,0.0008160087,0.00213295,0.00003688247,0.0001404911,0.00002220468,0.00001464997,0.0000145347],"genre_scores_gemma":[0.9973517,0.00007323575,0.0007101626,0.00163719,0.00007848042,0.00005237919,0.00005074504,0.00001439958,0.00003168867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.237961,"threshold_uncertainty_score":0.4031988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00985563523966528,"score_gpt":0.2484494590013668,"score_spread":0.2385938237617015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}