{"id":"W3092288940","doi":"10.1053/j.gastro.2020.09.043","title":"Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer","year":2020,"lang":"en","type":"article","venue":"Gastroenterology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":173,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cancer Council NSW; National Health and Medical Research Council; Engineering and Physical Sciences Research Council; Medical Research Council; National Institutes of Health; Queensland Government; Gastroenterological Society of Australia; Associazione Italiana per la Ricerca sul Cancro; University of Queensland; Royal Adelaide Hospital; Garvan Institute of Medical Research; Howat Foundation; Cancer Institute NSW; National Cancer Institute; Australian Cancer Research Foundation; Royal College of Surgeons of Edinburgh; University of Glasgow; Wellcome Trust; Cancer Research UK; Johns Hopkins University; Petre Foundation; Fondazione Italiana per la ricerca sulle Malattie del Pancreas; Pancreatic Cancer UK; Australian Government; Royal College of Physicians; University of California, San Francisco; Ministero della Salute; Ontario Institute for Cancer Research; Royal College of Pathologists of Australasia; R.T. Hall Trust; American Association for Cancer Research","keywords":"DNA damage; Replication (statistics); Pancreatic cancer; Cancer research; Fight-or-flight response; Medicine; Cancer; Oncology; DNA; Biology; Internal medicine; Genetics; Virology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003701652,0.0003322639,0.0003106685,0.0003878039,0.000178275,0.0006473027,0.0001968431,0.0003314559,0.0007357894],"category_scores_gemma":[0.0003061263,0.0001487068,0.0002198334,0.0003192638,0.0003857292,0.000380116,0.0003523403,0.0005878777,0.0001865569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004805624,"about_ca_system_score_gemma":0.0003754749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002759652,"about_ca_topic_score_gemma":0.0003799503,"domain_scores_codex":[0.9998274,0.00003223721,0.0000196821,0.00005133508,0.00004796386,0.00002144322],"domain_scores_gemma":[0.9996969,0.00005145772,0.0001468866,0.00003202489,0.00003858337,0.00003419093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004698773,0.00009956427,0.01947406,0.0003717335,0.00004042207,0.0001621276,0.00007147333,0.0007084435,0.9551647,0.0001966597,0.0001762645,0.02306461],"study_design_scores_gemma":[0.00004915815,0.002025098,0.1038957,0.00006790161,0.0001156373,0.00360136,0.0002099979,0.002740513,0.8777751,0.0006470017,0.008849,0.00002349943],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9772829,0.01411786,0.006277083,0.0004165614,0.0000340091,0.00007360333,0.0004278352,0.0001204719,0.00124954],"genre_scores_gemma":[0.9883277,0.00611286,0.004293928,0.0001491789,0.00002237772,0.0000417287,0.0004531576,0.0000136191,0.0005854083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007357894,"threshold_uncertainty_score":0.003486753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00985563523966528,"score_gpt":0.2484494590013668,"score_spread":0.2385938237617015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}