{"id":"W3092306676","doi":"10.7150/thno.47435","title":"IL-37 exerts therapeutic effects in experimental autoimmune encephalomyelitis through the receptor complex IL-1R5/IL-1R8","year":2020,"lang":"en","type":"article","venue":"Theranostics","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; Interleukin Foundation for Medical Research; Agencia Estatal de Investigación; National Institutes of Health; National Cancer Institute; Ministerio de Economía y Competitividad","keywords":"Experimental autoimmune encephalomyelitis; Multiple sclerosis; Immunology; Inflammation; Encephalomyelitis; Cytokine; Immune system; Receptor; Medicine; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000129282,0.0004130494,0.0005223906,0.00003365877,0.000222743,0.00003369206,0.0004822898,0.0002747276,0.00066264],"category_scores_gemma":[0.0000604493,0.000296265,0.0001706486,0.0002681245,0.000333953,0.0001045615,0.0001122945,0.0003007161,0.0006784986],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007765015,"about_ca_system_score_gemma":0.00005783392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001284358,"about_ca_topic_score_gemma":0.00001027732,"domain_scores_codex":[0.997871,0.0006260324,0.0004033185,0.0004412068,0.00008843058,0.0005699574],"domain_scores_gemma":[0.9986686,0.000697082,0.0001290035,0.0004322627,0.00003625915,0.00003677954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005827724,0.00031537,0.0007258318,0.00002761652,0.0004051158,0.00003086456,0.01446849,0.00001509868,0.9502005,0.002150753,0.001955235,0.02912236],"study_design_scores_gemma":[0.009370669,0.00174163,0.05167898,0.000149156,0.0003118236,0.00005531216,0.003003582,0.000067102,0.5753778,0.001161982,0.3560609,0.001021074],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9514893,0.03913336,0.0004438884,0.003042863,0.002286793,0.001444236,0.0002472256,0.0006325078,0.001279784],"genre_scores_gemma":[0.9958493,0.000825893,0.0002591874,0.002144298,0.0001652667,0.0001191986,0.0002117653,0.00009298172,0.0003321815],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3748227,"threshold_uncertainty_score":0.9999489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03332050038402508,"score_gpt":0.2609134369008505,"score_spread":0.2275929365168254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}