{"id":"W3092318873","doi":"10.1016/j.celrep.2020.108233","title":"Hyperactivity of Innate Immunity Triggers Pain via TLR2-IL-33-Mediated Neuroimmune Crosstalk","year":2020,"lang":"en","type":"article","venue":"Cell Reports","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; Alberta Children's Hospital; University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Innate immune system; TLR2; Neuroscience; Medicine; Spinal cord; Crosstalk; Downregulation and upregulation; Inflammation; Pattern recognition receptor; Immune system; Receptor; Immunology; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001015921,0.0003352278,0.0006727363,0.00009425346,0.0002710889,0.00001861149,0.0002432123,0.0003797981,0.0003188558],"category_scores_gemma":[0.001362384,0.0003199171,0.0002283356,0.0004168896,0.0003734012,0.0001708135,0.0001913298,0.0007468372,0.0001972681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003772089,"about_ca_system_score_gemma":0.0002616926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004421202,"about_ca_topic_score_gemma":0.00001150934,"domain_scores_codex":[0.9972443,0.0007220675,0.0008723058,0.0005307005,0.00009368675,0.0005369162],"domain_scores_gemma":[0.997896,0.000397476,0.0007318957,0.0007151785,0.0001761291,0.00008328895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002429355,0.000330575,0.00350053,0.0001189602,0.00009264852,0.0004962218,0.001035557,0.00001143303,0.9895444,0.000004725936,0.002234833,0.002387211],"study_design_scores_gemma":[0.001053855,0.000508833,0.0113431,0.00002484467,0.00006668396,0.0002628439,0.0002583719,0.00002570243,0.7137707,0.00004998843,0.2722431,0.0003919396],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895588,0.0008328037,0.0002551881,0.0001562349,0.001104806,0.00036326,0.000569851,0.0001791752,0.006979889],"genre_scores_gemma":[0.9977519,0.0002004649,0.00003087264,0.0004018839,0.00004129938,0.0000132084,0.0005517554,0.00004312725,0.0009654893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2757737,"threshold_uncertainty_score":0.9999253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01565230909390279,"score_gpt":0.2123014358472965,"score_spread":0.1966491267533937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}