{"id":"W3092334961","doi":"10.1158/1078-0432.ccr-20-2380","title":"Phase I Study of Lysine-Specific Demethylase 1 Inhibitor, CC-90011, in Patients with Advanced Solid Tumors and Relapsed/Refractory Non-Hodgkin Lymphoma","year":2020,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"National Institute for Health and Care Research; Cancer Research UK; Bristol-Myers Squibb","keywords":"Medicine; Internal medicine; Neutropenia; Lymphoma; Refractory (planetary science); Gastroenterology; Cancer; Context (archaeology); Oncology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008245725,0.0008208354,0.001272226,0.0002926211,0.0002737319,0.0005354097,0.0004685125,0.0004932591,0.001870758],"category_scores_gemma":[0.0004583854,0.0003946827,0.0005668387,0.0003204629,0.0005952292,0.0004912129,0.000220821,0.001600539,0.000480729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008590783,"about_ca_system_score_gemma":0.001217432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001256523,"about_ca_topic_score_gemma":0.004144393,"domain_scores_codex":[0.9997674,0.00009410843,0.00001594396,0.00004237498,0.00003418597,0.00004599234],"domain_scores_gemma":[0.9996139,0.00004362776,0.00007287445,0.00003272012,0.00003396049,0.0002028308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4178513,0.09152216,0.0580007,0.001532145,0.002270299,0.0006952276,0.0008801005,0.006239476,0.212723,0.000523593,0.006832924,0.2009291],"study_design_scores_gemma":[0.2752041,0.6413161,0.0583043,0.00005337622,0.0008078179,0.0008566461,0.0001694568,0.003150263,0.01459762,0.0002050667,0.005293105,0.00004223877],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965897,0.000977868,0.0002559364,0.0001098878,0.00002365956,0.0009189194,0.0003910675,0.00004157145,0.0006914394],"genre_scores_gemma":[0.9958442,0.0007418047,0.0008295401,0.0002421472,0.00003787082,0.0005568509,0.001012454,0.000009789468,0.0007253675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001870758,"threshold_uncertainty_score":0.006258309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08114341508681919,"score_gpt":0.4392745380252783,"score_spread":0.3581311229384591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}