{"id":"W3092399662","doi":"10.1253/circj.cj-20-0288","title":"Binge Alcohol Exposure Triggers Atrial Fibrillation Through T-Type Ca<sup>2+</sup> Channel Upregulation via Protein Kinase C (PKC) / Glycogen Synthesis Kinase 3β (GSK3β) / Nuclear Factor of Activated T-Cells (NFAT) Signaling　― An Experimental Account of Holiday Heart Syndrome ―","year":2020,"lang":"en","type":"article","venue":"Circulation Journal","topic":"Alcohol Consumption and Health Effects","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Canadian Institutes of Health Research","keywords":"Downregulation and upregulation; Kinase; Binge drinking; Signal transduction; Atrial fibrillation; Protein kinase A; Glycogen; Substrate (aquarium)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006644623,0.0002279224,0.000193183,0.0001082484,0.0001367365,0.0001617514,0.000120976,0.0001985468,0.002455172],"category_scores_gemma":[0.0001116775,0.00009178718,0.0001874044,0.00009020278,0.0002403106,0.0001777853,0.0002077592,0.0004365123,0.0001942239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002337071,"about_ca_system_score_gemma":0.0001488639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007101921,"about_ca_topic_score_gemma":0.001415323,"domain_scores_codex":[0.9999422,0.00000998354,0.000006447782,0.0000107825,0.00001323148,0.00001735346],"domain_scores_gemma":[0.9999318,0.000008291697,0.0000209004,0.000010223,0.000005680887,0.00002309941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002386234,0.00008677483,0.003504409,0.0000990294,0.00003065939,0.0004161503,0.00003581634,0.0000277709,0.9908922,0.00008257756,0.0001690884,0.002269198],"study_design_scores_gemma":[0.0002615529,0.002985246,0.2587889,0.00003606572,0.0001570615,0.002983364,0.0003406265,0.001323431,0.7286242,0.000453366,0.004025151,0.00002101605],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980199,0.0006326113,0.0005377411,0.0001315623,0.0000504706,0.00001489819,0.0001435527,0.00004181658,0.0004275291],"genre_scores_gemma":[0.9985595,0.0003665797,0.0002025486,0.00006590363,0.00001873248,0.00002204091,0.0001315991,0.000006281888,0.0006268154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002455172,"threshold_uncertainty_score":0.008213401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07920034775475378,"score_gpt":0.3204580859989994,"score_spread":0.2412577382442456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}