{"id":"W3092409574","doi":"10.1101/2020.10.08.331173","title":"Hsp90 and its co-chaperone Sti1 control TDP-43 misfolding and toxicity","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Fundação de Amparo à Pesquisa do Estado de São Paulo; Strong; Natural Sciences and Engineering Research Council of Canada; ALS Society of Canada","keywords":"Hsp90; Amyotrophic lateral sclerosis; Toxicity; Chaperone (clinical); Protein folding; Inclusion bodies; Protein aggregation; Co-chaperone; Cell biology; Heat shock protein; Neurodegeneration; Biology; Chemistry; Biochemistry; Medicine; Disease; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001053209,0.0001884458,0.0002002169,0.0001643151,0.0001074365,0.0003244405,0.000132564,0.0001949888,0.001362488],"category_scores_gemma":[0.0001120314,0.0000861369,0.0001146523,0.0001402488,0.0001514148,0.0001481656,0.0001559556,0.0003257568,0.0005284514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002726704,"about_ca_system_score_gemma":0.0001061428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003421532,"about_ca_topic_score_gemma":0.0003918587,"domain_scores_codex":[0.9999278,0.00001193319,0.000005659899,0.00001316376,0.00002074984,0.00002083512],"domain_scores_gemma":[0.999928,0.000006948126,0.00002605072,0.00000738288,0.000008336082,0.00002325227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001778505,0.00002601508,0.0004447679,0.00002819596,0.000004427485,0.00004175821,0.000009385097,0.0001105378,0.9970879,0.00009010291,0.0001585922,0.001820523],"study_design_scores_gemma":[0.00001701002,0.0001628701,0.01635262,0.000007447033,0.00001393641,0.0002299664,0.00003884764,0.002618986,0.9782853,0.0001282595,0.002141179,0.000003485917],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924098,0.003354421,0.001625778,0.0002254677,0.00003280156,0.00001324071,0.0004303737,0.0001248563,0.001783316],"genre_scores_gemma":[0.9971355,0.0004924982,0.0004791029,0.000034333,0.00000845054,0.000007562896,0.0001921052,0.00001551129,0.00163492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001362488,"threshold_uncertainty_score":0.004557908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03148551815529928,"score_gpt":0.2688169690382373,"score_spread":0.237331450882938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}