{"id":"W3092410821","doi":"10.1038/s41467-020-18865-z","title":"Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Heart, Lung, and Blood Institute; University of Toronto; Muscular Dystrophy Association; Cancer Prevention and Research Institute of Texas; American Heart Association; National Cancer Institute; National Institutes of Health; U.S. Department of Health and Human Services; Howard Hughes Medical Institute","keywords":"RYR1; Thermogenesis; Malignant hyperthermia; Endocrinology; Internal medicine; Ryanodine receptor; Brown adipose tissue; Skeletal muscle; Biology; Hyperthermia; Mutation; Adipose tissue; Receptor; Medicine; Gene; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002652973,0.0006559229,0.0003951947,0.0007193225,0.0002003882,0.0003173689,0.0002433254,0.0005311184,0.003450177],"category_scores_gemma":[0.0001889012,0.000318092,0.0004691627,0.0002130268,0.0005415422,0.000247955,0.0004194597,0.0008049863,0.0003688962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000211614,"about_ca_system_score_gemma":0.000142341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003038348,"about_ca_topic_score_gemma":0.0005037162,"domain_scores_codex":[0.9997342,0.00007319974,0.00003582731,0.00006174568,0.00004894417,0.0000459079],"domain_scores_gemma":[0.999575,0.00005605053,0.0001700876,0.00002810807,0.00001608594,0.0001547532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005009667,0.00007589128,0.0004170473,0.00002545972,0.00001258417,0.000174552,0.00002267509,0.00006486863,0.9977682,0.00009795767,0.00006143987,0.0007783998],"study_design_scores_gemma":[0.0004109312,0.004073922,0.05930023,0.00006164546,0.0001419257,0.003845652,0.0002434259,0.002896785,0.9244062,0.0004858572,0.004082091,0.00005127773],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968691,0.0003191015,0.001438844,0.0001626342,0.00004269071,0.00001904633,0.0004771003,0.0001429883,0.0005284689],"genre_scores_gemma":[0.9939185,0.0003874909,0.001966082,0.0001387024,0.00003034496,0.00006922646,0.0004858467,0.0001096975,0.00289406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003450177,"threshold_uncertainty_score":0.01154202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0401242066879381,"score_gpt":0.3274184423511164,"score_spread":0.2872942356631783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}