{"id":"W3092432246","doi":"10.1097/shk.0000000000001679","title":"Calpain Activation and Organ Failure in Sepsis: Molecular Insights and Therapeutic Perspectives","year":2020,"lang":"en","type":"review","venue":"Shock","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; London Health Sciences Centre; Lawson Health Research Institute; University of Toronto","funders":"","keywords":"Calpastatin; Calpain; Sepsis; Organ dysfunction; Proteases; Medicine; Immunology; Cysteine protease; Pathogenesis; Bioinformatics; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006469665,0.0002277397,0.0003657337,0.00008912283,0.00004318914,0.00003011744,0.00005364587,0.0003300895,0.000008184472],"category_scores_gemma":[0.00004916309,0.0001873268,0.000081757,0.000158355,0.00005419561,0.000003083703,0.0000643919,0.0001708897,0.000002310126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003358821,"about_ca_system_score_gemma":0.00009415616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005756984,"about_ca_topic_score_gemma":0.00002030484,"domain_scores_codex":[0.9990153,0.0001767067,0.0001845458,0.000440526,0.00008032676,0.0001026303],"domain_scores_gemma":[0.9996523,0.00001318392,0.00008763653,0.0001524632,0.00002936348,0.00006510793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003820122,0.00004355895,0.00001648016,0.002416464,0.0002520908,0.00001105612,0.0004954836,0.000003273609,0.01210457,0.0008150015,0.0002480809,0.9835557],"study_design_scores_gemma":[0.000250993,0.00009385412,0.00003124118,0.0006247305,0.00009438907,0.00001877773,0.000335006,0.00004028236,0.0006939601,0.0001712325,0.9973796,0.0002659525],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001212528,0.9968407,0.001081892,0.0002191229,0.00002788002,0.0005155352,0.000004193786,0.00001315893,0.00008502773],"genre_scores_gemma":[0.01979144,0.9794705,0.0001264123,0.0001436416,0.0001327319,0.00003612096,0.00013527,0.00003865606,0.0001252228],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9971315,"threshold_uncertainty_score":0.7638965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01122002832570002,"score_gpt":0.2657016995753516,"score_spread":0.2544816712496516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}