{"id":"W3092432246","doi":"10.1097/shk.0000000000001679","title":"Calpain Activation and Organ Failure in Sepsis: Molecular Insights and Therapeutic Perspectives","year":2020,"lang":"en","type":"review","venue":"Shock","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; London Health Sciences Centre; Lawson Health Research Institute; University of Toronto","funders":"","keywords":"Calpastatin; Calpain; Sepsis; Organ dysfunction; Proteases; Medicine; Immunology; Cysteine protease; Pathogenesis; Bioinformatics; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004468739,0.0006815432,0.0009092643,0.001359471,0.0002174441,0.0008342937,0.0006876991,0.001063316,0.003085717],"category_scores_gemma":[0.0004950648,0.0001540852,0.0004076407,0.001193278,0.0003238493,0.0009826022,0.0006214852,0.002022624,0.00122232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004696737,"about_ca_system_score_gemma":0.0009309229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004938422,"about_ca_topic_score_gemma":0.0009196413,"domain_scores_codex":[0.9998853,0.00001966935,0.00001553351,0.00001902488,0.00004427486,0.00001630245],"domain_scores_gemma":[0.999809,0.00006674672,0.00002584836,0.000005699866,0.00006595935,0.00002677928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001898225,0.0001350047,0.0002176469,0.01910787,0.0001151389,0.0003735182,0.00007656845,0.0004455892,0.005401742,0.005258208,0.04061747,0.9280613],"study_design_scores_gemma":[0.00005146288,0.0002823199,0.001525238,0.004850689,0.0001899374,0.00248616,0.00008874739,0.0002332781,0.001168131,0.00353655,0.9855601,0.00002739005],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001320484,0.9986346,0.00009818721,0.0003575081,0.000268458,0.000002572266,0.00001207851,0.000005951474,0.0004885091],"genre_scores_gemma":[0.0007064091,0.998389,0.0001028514,0.0001918974,0.0002272202,0.000003807669,0.00002244438,8.626469e-7,0.0003554551],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003085717,"threshold_uncertainty_score":0.01032269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01122002832570002,"score_gpt":0.2657016995753516,"score_spread":0.2544816712496516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}