{"id":"W3092439654","doi":"10.1111/bcp.14598","title":"Efficacy and safety outcomes of proposed randomized controlled trials investigating hydroxychloroquine and chloroquine during the early stages of the COVID‐19 pandemic","year":2020,"lang":"en","type":"review","venue":"British Journal of Clinical Pharmacology","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Hydroxychloroquine; Medicine; Clinical trial; Interquartile range; Randomized controlled trial; Surrogate endpoint; Chloroquine; Adverse effect; Pandemic; Intensive care medicine; Internal medicine; Coronavirus disease 2019 (COVID-19); Malaria; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.1128302,0.001557423,0.006173595,0.003029842,0.0008951967,0.004421173,0.001419589,0.005603419,0.008599886],"category_scores_gemma":[0.2636063,0.0009573149,0.01324233,0.00359766,0.002205859,0.003124911,0.001442977,0.0030636,0.0009348436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003687742,"about_ca_system_score_gemma":0.006350203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007933166,"about_ca_topic_score_gemma":0.001599058,"domain_scores_codex":[0.7922166,0.1426192,0.04880114,0.006172745,0.00871399,0.001476267],"domain_scores_gemma":[0.7236684,0.2039577,0.05267457,0.006432668,0.01177492,0.001491852],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.1883024,0.001144718,0.01347634,0.5280108,0.1725745,0.0002580127,0.0004990341,0.001496045,0.001390929,0.003533059,0.004247568,0.0850665],"study_design_scores_gemma":[0.3988062,0.03404013,0.0330461,0.1676732,0.3290834,0.0005878267,0.0004876158,0.001983994,0.003071131,0.006148544,0.02483816,0.0002336391],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1094615,0.7833156,0.009626192,0.0111824,0.003916779,0.05769562,0.0128043,0.000237357,0.01176031],"genre_scores_gemma":[0.7744069,0.1185121,0.01736317,0.007170143,0.001558475,0.07364542,0.005721651,0.00007849831,0.001543736],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8871698,"threshold_uncertainty_score":0.5967104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2005083471592396,"score_gpt":0.5391468610162741,"score_spread":0.3386385138570345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}