{"id":"W3092498650","doi":"10.3389/fbioe.2020.583970","title":"Developmentally-Inspired Biomimetic Culture Models to Produce Functional Islet-Like Cells From Pluripotent Precursors","year":2020,"lang":"en","type":"review","venue":"Frontiers in Bioengineering and Biotechnology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Michigan Diabetes Research Center, University of Michigan; Stem Cell Network; Centre québécois sur les matériaux fonctionnels; Diabète Québec; Canada Research Chairs; McGill University","keywords":"Cell biology; Induced pluripotent stem cell; Embryonic stem cell; Mechanobiology; Cellular differentiation; Biology; Progenitor cell; Directed differentiation; Extracellular matrix; Cell culture; Cell; Context (archaeology); Stem cell; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008910707,0.000573832,0.001751434,0.0008218582,0.00004705092,0.00002397525,0.0001826871,0.001039674,0.00001422259],"category_scores_gemma":[0.00006601593,0.0004688907,0.0001790605,0.0008963297,0.0001041479,0.00004360404,0.0001529477,0.0006834287,0.00003576791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003007941,"about_ca_system_score_gemma":0.0001630307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001853161,"about_ca_topic_score_gemma":7.36003e-7,"domain_scores_codex":[0.9978741,0.00002880723,0.0005659696,0.000906559,0.000196145,0.0004283631],"domain_scores_gemma":[0.9992514,0.00002430047,0.0001117626,0.0003523457,0.00002929421,0.0002309167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009776141,0.0001375819,0.00002806386,0.005170101,0.0009832474,0.0001018593,0.0002313764,0.0001163554,0.002344185,0.00006620458,0.03385996,0.9568633],"study_design_scores_gemma":[0.0005967551,0.0002073426,0.000007116116,0.003832476,0.0004785022,0.00004213569,0.0001023478,0.001587554,0.00176955,0.00004544535,0.9908303,0.0005004715],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004816461,0.9781454,0.01689836,0.0007198959,0.002057511,0.001133905,0.0001057755,0.0004065301,0.00005095499],"genre_scores_gemma":[0.0001722491,0.9334265,0.0650685,0.0002239729,0.0001721382,0.0001668223,0.000302093,0.000068388,0.0003993414],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9569703,"threshold_uncertainty_score":0.9997763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02255814021023973,"score_gpt":0.2267826469948044,"score_spread":0.2042245067845647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}