{"id":"W3092504886","doi":"10.1016/j.matbio.2020.10.002","title":"Latent-transforming growth factor beta-binding protein-2 (LTBP-2) is required for longevity but not for development of zonular fibers","year":2020,"lang":"en","type":"article","venue":"Matrix Biology","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Eye Institute; National Heart, Lung, and Blood Institute; National Health and Medical Research Council; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Marfan Foundation; Research to Prevent Blindness","keywords":"Fibrillin; In vivo; Cell biology; Extracellular; Chemistry; Transforming growth factor beta; Transforming growth factor; Biophysics; Extracellular matrix; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002303942,0.0002068251,0.000338901,0.00006416485,0.0001275891,0.000010851,0.000290488,0.0002569744,0.00003681922],"category_scores_gemma":[0.0002971601,0.0001984274,0.0001937056,0.0001008558,0.00009863116,0.000006011577,0.0001225132,0.00008108115,0.000007713206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003000221,"about_ca_system_score_gemma":0.0001685798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001804572,"about_ca_topic_score_gemma":0.00002145493,"domain_scores_codex":[0.9984868,0.00005290526,0.0003746109,0.0005335712,0.00009623916,0.0004558433],"domain_scores_gemma":[0.9993106,0.00005364103,0.0001246691,0.0001763208,0.0002264799,0.0001083539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006416861,0.00002883322,0.001469541,0.0003653161,0.0001765096,5.256421e-7,0.0004539208,7.211004e-7,0.9896074,0.0002285424,0.00009985451,0.006927147],"study_design_scores_gemma":[0.00122577,0.0006957698,0.0001507275,0.00001311701,0.00001941867,0.000001018836,0.0001196637,0.00005497547,0.9789079,0.00007921119,0.0184989,0.0002335689],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9526044,0.0003424876,0.04356993,0.001097009,0.00005106181,0.001820348,0.0004728673,0.00001673368,0.00002513275],"genre_scores_gemma":[0.9889242,0.00002537402,0.009743639,0.0001114697,0.00008923354,0.0003461597,0.000409738,0.00003689865,0.0003133068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03631975,"threshold_uncertainty_score":0.8091636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05812411550240275,"score_gpt":0.3329975396020443,"score_spread":0.2748734240996416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}