{"id":"W3092527012","doi":"10.1186/s13024-020-00407-2","title":"Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration","year":2020,"lang":"en","type":"article","venue":"Molecular Neurodegeneration","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute on Aging; Perelman School of Medicine, University of Pennsylvania; Canadian Institutes of Health Research; Deutsches Zentrum für Neurodegenerative Erkrankungen; Gemeinnützige Hertie-Stiftung; University of Pennsylvania","keywords":"TREM2; Neurodegeneration; Medicine; Cognitive decline; Microglia; Apolipoprotein E; Dementia; Internal medicine; Neurology; Neuroscience; Psychology; Disease; Psychiatry; Inflammation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009042391,0.0004798805,0.0005230309,0.0003110117,0.0001699819,0.0003365539,0.000290232,0.00035266,0.001678286],"category_scores_gemma":[0.001873908,0.0001856329,0.000391962,0.0002188386,0.000193575,0.0001832579,0.0003635438,0.0004123659,0.000220484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002134158,"about_ca_system_score_gemma":0.0003296049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002433938,"about_ca_topic_score_gemma":0.001880231,"domain_scores_codex":[0.9997148,0.000128546,0.00001361822,0.00005095175,0.00004826712,0.00004382099],"domain_scores_gemma":[0.9990352,0.000280702,0.0003201244,0.0001138774,0.00008136673,0.0001687243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0370998,0.002304665,0.8514038,0.000128805,0.001401421,0.0005590016,0.0003286809,0.0009044528,0.07809552,0.0001135566,0.0004434136,0.027217],"study_design_scores_gemma":[0.00008656726,0.001733572,0.9923927,0.000005635271,0.0001526985,0.0001479479,0.0000455345,0.001144826,0.003994177,0.00007082596,0.0002196216,0.000005973892],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996221,0.000111234,0.00008231068,0.00001700739,0.000002111847,0.000002249763,0.00004514738,0.000008323984,0.000109358],"genre_scores_gemma":[0.999363,0.00003912023,0.0001396253,0.00001598392,0.000005113076,0.000004195465,0.00009579172,0.000003175135,0.0003339961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002433938,"threshold_uncertainty_score":0.00561446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03254590442375969,"score_gpt":0.257740899066693,"score_spread":0.2251949946429333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}