{"id":"W3092552341","doi":"10.1002/1878-0261.12817","title":"Tumor and germline next generation sequencing in high grade serous cancer: experience from a large population‐based testing program","year":2020,"lang":"en","type":"article","venue":"Molecular Oncology","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Princess Margaret Cancer Foundation; AstraZeneca Canada","keywords":"Germline; Concordance; Genetic testing; Population; Cancer; Oncology; Medicine; Serous fluid; Germline mutation; Somatic cell; Internal medicine; Biology; Genetics; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003203796,0.0002396695,0.0001442165,0.0003212429,0.0003886648,0.0003832107,0.0002989595,0.0002773331,0.0006756007],"category_scores_gemma":[0.004221868,0.0001577518,0.0001393383,0.0002688832,0.0005122403,0.0002454867,0.0005758192,0.0003850996,0.0001985189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002363516,"about_ca_system_score_gemma":0.0009263063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002857052,"about_ca_topic_score_gemma":0.003473741,"domain_scores_codex":[0.9986584,0.0008058191,0.00004175241,0.0002163784,0.0002112495,0.00006643045],"domain_scores_gemma":[0.9979295,0.001054715,0.0001881137,0.0002192738,0.0002572379,0.0003512439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000724557,0.001652818,0.8359641,0.00006165999,0.0000777502,0.001846891,0.004545582,0.001116495,0.01656374,0.0002279909,0.0009547517,0.1362637],"study_design_scores_gemma":[0.0003096325,0.008190969,0.9500111,0.00005590474,0.0001317089,0.01132101,0.002636119,0.00581954,0.01313555,0.00053853,0.007794217,0.0000556386],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974485,0.000162707,0.001475221,0.00008633405,0.000005655323,0.00004544798,0.00004416435,0.00002627714,0.0007055536],"genre_scores_gemma":[0.9967541,0.0002445108,0.002435505,0.0001400513,0.00001414189,0.00003061063,0.0001333976,0.00001322641,0.0002344619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003203796,"threshold_uncertainty_score":0.01694351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0709129825684013,"score_gpt":0.3369060024410211,"score_spread":0.2659930198726198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}