{"id":"W3092578600","doi":"10.1126/scisignal.abb4778","title":"RASSF effectors couple diverse RAS subfamily GTPases to the Hippo pathway","year":2020,"lang":"en","type":"article","venue":"Science Signaling","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Israel Science Foundation; Canada Research Chairs; United States-Israel Binational Science Foundation","keywords":"Subfamily; Effector; GTPase; Hippo signaling pathway; Biology; Cell biology; Kinase; Protein-Serine-Threonine Kinases; Genetics; Protein kinase A; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001037208,0.0002025661,0.0001616089,0.00005773857,0.0006199682,0.0001374922,0.0008415228,0.00007396644,0.00004812894],"category_scores_gemma":[0.0007445972,0.000147803,0.0001126975,0.0007124315,0.0003173422,0.00001251371,0.0002853012,0.0001447922,0.0001855151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000232839,"about_ca_system_score_gemma":0.0003196012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004692375,"about_ca_topic_score_gemma":0.00001049523,"domain_scores_codex":[0.9980233,0.00008725819,0.0002087949,0.0006677407,0.0004891812,0.0005237173],"domain_scores_gemma":[0.9989669,0.00005427869,0.00007316012,0.0003755215,0.0001527772,0.0003773161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003561025,0.00001498843,0.000918436,0.000008798539,0.000009172708,0.000007671343,0.0005935535,0.003853554,0.99231,0.00004081578,0.0003344297,0.001872973],"study_design_scores_gemma":[0.0002414806,0.0003716975,0.0002027104,0.00002253885,0.00001257778,0.000003645477,0.0005763023,0.000910808,0.9789504,0.00001982411,0.01843331,0.0002546371],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942091,0.0002971415,0.003605056,0.0008361769,0.0003494712,0.0002843877,0.0000292075,0.00004765406,0.000341828],"genre_scores_gemma":[0.9958662,0.000009744303,0.0004014722,0.003039772,0.0005218247,0.00002051937,0.00001728838,0.00001993832,0.0001032795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01809888,"threshold_uncertainty_score":0.6027231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02182988451239463,"score_gpt":0.249519919089442,"score_spread":0.2276900345770473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}