{"id":"W3092589414","doi":"10.1139/bcb-2020-0219","title":"Circ_0000043 promotes the proliferation, migration, invasiveness, and epithelial–mesenchymal transition in breast cancer cells via the miR-136–Smad3 axis","year":2020,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Circular RNAs in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Xinjiang Medical University; National Natural Science Foundation of China","keywords":"Epithelial–mesenchymal transition; Vimentin; Gene knockdown; Western blot; Cell growth; Immunohistochemistry; Cancer research; SMAD; Cell migration; Chemistry; Luciferase; microRNA; Molecular biology; Biology; Transition (genetics); Cell; Cell culture; Cell biology; Transfection; Signal transduction; Gene; Immunology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002396428,0.0003991128,0.0003423507,0.0003965155,0.0003637688,0.0003965423,0.0001502566,0.0002833861,0.001772102],"category_scores_gemma":[0.0002602745,0.0002083461,0.0004843128,0.0003583341,0.0003117676,0.0001687562,0.0002210934,0.0006899856,0.0005660114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003112146,"about_ca_system_score_gemma":0.0005199074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000821477,"about_ca_topic_score_gemma":0.001194387,"domain_scores_codex":[0.9997805,0.00003278952,0.00003107725,0.00003530823,0.00007715837,0.00004316547],"domain_scores_gemma":[0.9998724,0.00002116309,0.00004294155,0.00001070913,0.00002462908,0.00002804552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006526133,0.0001532226,0.001909776,0.0002559673,0.00003735929,0.0001778991,0.00006200047,0.0002574389,0.9874964,0.0003289263,0.0008299038,0.007838532],"study_design_scores_gemma":[0.0001816936,0.001336616,0.02482375,0.00002687321,0.000158672,0.0009812067,0.0001370657,0.004337583,0.9491405,0.0001840462,0.01866373,0.00002836128],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829493,0.005814524,0.003358488,0.0003939582,0.0002099255,0.00008550342,0.00115581,0.0003526261,0.005679793],"genre_scores_gemma":[0.98592,0.003319855,0.003502455,0.0004745851,0.0000674453,0.0001243074,0.002409446,0.00007430936,0.004107603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001772102,"threshold_uncertainty_score":0.005928278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006239378717143361,"score_gpt":0.2099310487015725,"score_spread":0.2036916699844292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}