{"id":"W3092618405","doi":"10.1016/j.bbalip.2020.158824","title":"Myocardin suppression increases lipid retention and atherosclerosis via downregulation of ABCA1 in vascular smooth muscle cells","year":2020,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"ABCA1; Myocardin; Internal medicine; Endocrinology; Cholesterol; Gene knockdown; Vascular smooth muscle; Downregulation and upregulation; Efflux; Medicine; Chemistry; Transporter; Biology; Gene expression; Serum response factor; Biochemistry; Apoptosis; Smooth muscle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002663646,0.0004517221,0.0004886232,0.0003020586,0.0003666769,0.0004608826,0.0002437575,0.0004371419,0.002348203],"category_scores_gemma":[0.0002052312,0.0002931707,0.0004301293,0.0002216056,0.0004832996,0.0003694362,0.0003196631,0.001236814,0.0005304802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002619654,"about_ca_system_score_gemma":0.0003395592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000518551,"about_ca_topic_score_gemma":0.0007895943,"domain_scores_codex":[0.9997308,0.00003756598,0.00002704618,0.00005556999,0.00004581319,0.0001032432],"domain_scores_gemma":[0.9998386,0.00001955785,0.00004273514,0.00001869722,0.00001715619,0.00006318036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008885613,0.00009478778,0.0003480406,0.00006229141,0.00001532927,0.00008465194,0.00003107226,0.00004220824,0.9967715,0.0001650954,0.0001244881,0.001371894],"study_design_scores_gemma":[0.0002886804,0.001517058,0.02131588,0.00002029876,0.0001675474,0.0003519114,0.0002528154,0.001300043,0.9650975,0.0002174374,0.009453563,0.00001736007],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941596,0.002242094,0.00120915,0.0003653149,0.0001943478,0.00001688043,0.0002460418,0.0001158629,0.001450762],"genre_scores_gemma":[0.9933983,0.001382127,0.000693019,0.0001607244,0.00006196248,0.00005367497,0.0004907948,0.00003001572,0.003729315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002348203,"threshold_uncertainty_score":0.007855535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01134825941905925,"score_gpt":0.2249783335211351,"score_spread":0.2136300741020758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}