{"id":"W3092628075","doi":"10.1371/journal.ppat.1008948","title":"BH3-only sensors Bad, Noxa and Puma are Key Regulators of Tacaribe virus-induced Apoptosis","year":2020,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada","funders":"Deutsche Forschungsgemeinschaft; Friedrich-Loeffler-Institut","keywords":"Puma; Junin virus; Arenavirus; Apoptosis; Biology; Virus; Cell biology; Gene silencing; Virology; Lassa virus; Small interfering RNA; Immunology; Lymphocytic choriomeningitis; Immune system; Cell culture; Genetics; Transfection; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001236486,0.0002939723,0.00025365,0.0002025502,0.0002337154,0.0003503172,0.0001549403,0.0002312228,0.0008291498],"category_scores_gemma":[0.0001192123,0.0001108206,0.000242029,0.0001365906,0.0001892993,0.0003296171,0.0002496071,0.0005298205,0.0002495105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001726756,"about_ca_system_score_gemma":0.0001328206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001574384,"about_ca_topic_score_gemma":0.0002087776,"domain_scores_codex":[0.9998314,0.00002267376,0.00001385057,0.00003029137,0.00005240737,0.00004935364],"domain_scores_gemma":[0.9999025,0.00001175813,0.00003007197,0.00001136138,0.00001885445,0.00002553716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001400457,0.00001400391,0.000493791,0.00004205808,0.000005184352,0.00004167387,0.00001418169,0.0000224384,0.9978166,0.0001384604,0.00002368625,0.001247796],"study_design_scores_gemma":[0.00001839133,0.0002151928,0.019875,0.00000665403,0.00002118219,0.0006725555,0.00005923359,0.0009090013,0.974961,0.0002948605,0.002960138,0.000006857295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983687,0.006297012,0.007317732,0.000155985,0.00005813241,0.00002860661,0.0004559629,0.0001181756,0.001881392],"genre_scores_gemma":[0.9948649,0.001440448,0.001508895,0.00005335721,0.00001470007,0.00002394708,0.0005091951,0.000007924604,0.001576744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008291498,"threshold_uncertainty_score":0.002773821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04617177880407437,"score_gpt":0.2827609894747573,"score_spread":0.2365892106706829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}