{"id":"W3092641626","doi":"10.1161/circresaha.120.317054","title":"Genome-Wide Analysis Identifies an Essential Human TBX3 Pacemaker Enhancer","year":2020,"lang":"en","type":"article","venue":"Circulation Research","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Heart, Lung, and Blood Institute; Hartstichting; ZonMw; Fondation pour la Recherche Médicale; Fondation Leducq","keywords":"Biology; Enhancer; Homeobox; Transcription factor; Sinoatrial node; Embryonic stem cell; Cell biology; Induced pluripotent stem cell; Genetics; Gene; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001255877,0.0002263111,0.0002472543,0.0002877012,0.0001880228,0.0002249371,0.0001320095,0.0002720916,0.002300072],"category_scores_gemma":[0.0001348225,0.00009791025,0.0002926569,0.0002721946,0.0001586899,0.0000435133,0.0002033081,0.0002813401,0.0004424542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001508061,"about_ca_system_score_gemma":0.0001792225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001356008,"about_ca_topic_score_gemma":0.002591471,"domain_scores_codex":[0.9999231,0.000005672858,0.000004666633,0.00003237586,0.00002265029,0.00001149638],"domain_scores_gemma":[0.9999243,0.00002589405,0.00002036017,0.000006447274,0.000006845359,0.00001614228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009459506,0.00005356842,0.03227865,0.0001477285,0.0001338377,0.001495469,0.00007895395,0.0006572425,0.9496096,0.0002333555,0.0008586868,0.01350711],"study_design_scores_gemma":[0.0002888686,0.0003518125,0.6208423,0.00007177363,0.0005063826,0.01027972,0.0001677633,0.006836976,0.3429578,0.0005786993,0.01708382,0.00003403534],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899257,0.001054618,0.003950051,0.000132453,0.00001532086,0.00003232325,0.003621798,0.0001664843,0.001101129],"genre_scores_gemma":[0.9927633,0.0002798544,0.002086288,0.0001550724,0.000009100186,0.00002084357,0.003919939,0.00003716232,0.0007284684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002300072,"threshold_uncertainty_score":0.007694542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06937669920896256,"score_gpt":0.4046823144986784,"score_spread":0.3353056152897159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}