{"id":"W3092687430","doi":"10.1099/mgen.0.000454","title":"Azithromycin resistance mutations in Streptococcus pneumoniae as revealed by a chemogenomic screen","year":2020,"lang":"en","type":"article","venue":"Microbial Genomics","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"23S ribosomal RNA; Streptococcus pneumoniae; Mutagenesis; Azithromycin; Biology; Glutamine; Mutant; Gene; Ribosomal RNA; Mutation; Genetics; Microbiology; Phenotype; Ribosomal protein; Bacterial genetics; Antibiotics; RNA; Escherichia coli; Ribosome; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00009886672,0.0002296635,0.0004006722,0.0001052086,0.0001368697,0.00003584761,0.0001535022,0.0001589187,0.0001445141],"category_scores_gemma":[0.000096909,0.0002459055,0.000136905,0.000409591,0.0001109811,0.00006565056,0.000060444,0.0003766494,0.0004641721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002872283,"about_ca_system_score_gemma":0.0003736466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005896073,"about_ca_topic_score_gemma":0.0002375467,"domain_scores_codex":[0.9985546,0.00005464851,0.0004741107,0.0004544918,0.00009948799,0.0003626901],"domain_scores_gemma":[0.9992275,0.00003934233,0.000120876,0.0002845138,0.00005926256,0.0002685621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007383176,0.0001117501,0.007415731,0.00004779824,0.00004556256,0.00006855153,0.0009452344,0.00004974848,0.9829916,0.0000329135,0.007885218,0.0003320033],"study_design_scores_gemma":[0.008485006,0.0006913028,0.04542227,0.0002294456,0.0003027556,0.000143508,0.0007512934,0.0001567461,0.1602801,0.0001903782,0.7822143,0.001132824],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864595,0.0002706382,0.00007609127,0.008545639,0.0000870519,0.0008845822,0.0002416553,0.00009970595,0.003335166],"genre_scores_gemma":[0.9924055,0.00009154256,0.0002897902,0.005340857,0.0002459071,0.0000432645,0.0001416358,0.00006151422,0.001379968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8227115,"threshold_uncertainty_score":0.9999993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01349295318022889,"score_gpt":0.2480878647080045,"score_spread":0.2345949115277756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}