{"id":"W3092687430","doi":"10.1099/mgen.0.000454","title":"Azithromycin resistance mutations in Streptococcus pneumoniae as revealed by a chemogenomic screen","year":2020,"lang":"en","type":"article","venue":"Microbial Genomics","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"23S ribosomal RNA; Streptococcus pneumoniae; Mutagenesis; Azithromycin; Biology; Glutamine; Mutant; Gene; Ribosomal RNA; Mutation; Genetics; Microbiology; Phenotype; Ribosomal protein; Bacterial genetics; Antibiotics; RNA; Escherichia coli; Ribosome; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002082652,0.0004685272,0.000529202,0.0005026715,0.0002029349,0.0003612479,0.0002734126,0.0004408138,0.0006815721],"category_scores_gemma":[0.0004864443,0.0001632076,0.0003410194,0.0005081299,0.0001653862,0.0001260434,0.0003207493,0.0002944169,0.0003446263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002250925,"about_ca_system_score_gemma":0.0002178396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001038585,"about_ca_topic_score_gemma":0.002410104,"domain_scores_codex":[0.9996402,0.00003857795,0.00002360844,0.00009718847,0.0001608706,0.00003951585],"domain_scores_gemma":[0.999772,0.00005609276,0.00006151701,0.00002830534,0.00005246076,0.00002971318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00003799413,0.00002009672,0.001302334,0.00004639028,0.0000163378,0.00007231179,0.00001671956,0.0001150927,0.9948936,0.00002319254,0.00005102396,0.003404942],"study_design_scores_gemma":[0.0000107629,0.0006027664,0.06749594,0.00002386196,0.0001648876,0.00154031,0.0001333023,0.005483482,0.9185007,0.0001388978,0.005866914,0.00003818731],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.973087,0.001845113,0.01519905,0.0002385208,0.00004751645,0.0001740632,0.006564472,0.000553696,0.002290586],"genre_scores_gemma":[0.9658652,0.001451956,0.02394054,0.0002675074,0.00001628322,0.0001134913,0.005802645,0.0001462456,0.002396195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001038585,"threshold_uncertainty_score":0.002280116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01349295318022889,"score_gpt":0.2480878647080045,"score_spread":0.2345949115277756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}