{"id":"W3092703989","doi":"10.1038/s41467-020-19138-5","title":"GPAHex-A synthetic biology platform for Type IV–V glycopeptide antibiotic production and discovery","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Glycopeptide; Glycopeptide antibiotic; Antibiotics; Synthetic biology; Biology; Computational biology; Drug discovery; Microbiology; Bioinformatics; Bacteria; Genetics; Vancomycin; Staphylococcus aureus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002690184,0.0004292269,0.0002363119,0.0002666644,0.0001860446,0.0004707463,0.0002506772,0.0002921874,0.00183383],"category_scores_gemma":[0.0002030903,0.0001986843,0.0003453156,0.0002292705,0.0002305049,0.0004552289,0.0006255911,0.001021186,0.001206815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002350592,"about_ca_system_score_gemma":0.0004139537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002261698,"about_ca_topic_score_gemma":0.0003239034,"domain_scores_codex":[0.9998335,0.00002514903,0.00001060676,0.00002898895,0.00007315989,0.00002859472],"domain_scores_gemma":[0.9998957,0.00001117727,0.00002348684,0.00002058122,0.00001463826,0.00003438495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001101157,0.00004877738,0.0001640995,0.00006332534,0.00000778362,0.0001241068,0.00002169327,0.0006456985,0.9848701,0.002474297,0.0004779895,0.01099207],"study_design_scores_gemma":[0.00002698083,0.0004409077,0.0004660101,0.00001232369,0.000009054778,0.0003712174,0.0000180748,0.002464463,0.9684239,0.0005775761,0.02717454,0.00001499032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6140869,0.003184966,0.3379318,0.001360482,0.0005658682,0.0008137432,0.005185733,0.003793759,0.03307677],"genre_scores_gemma":[0.7787961,0.003720308,0.1977796,0.0003235145,0.00008503186,0.0002873648,0.004249191,0.0003115977,0.0144473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00183383,"threshold_uncertainty_score":0.006134748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05040571091131332,"score_gpt":0.31993623118786,"score_spread":0.2695305202765467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}