{"id":"W3092703989","doi":"10.1038/s41467-020-19138-5","title":"GPAHex-A synthetic biology platform for Type IV–V glycopeptide antibiotic production and discovery","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Glycopeptide; Glycopeptide antibiotic; Antibiotics; Synthetic biology; Biology; Computational biology; Drug discovery; Microbiology; Bioinformatics; Bacteria; Genetics; Vancomycin; Staphylococcus aureus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001336062,0.0001188671,0.0002196097,0.00005052121,0.0001930672,0.00002845853,0.0002416173,0.0002189819,0.000009593607],"category_scores_gemma":[0.002056234,0.00008791247,0.00005358,0.0002540124,0.0001721008,0.0001268642,0.0001557806,0.0005091148,0.00001143066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002531968,"about_ca_system_score_gemma":0.00005386068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007999642,"about_ca_topic_score_gemma":0.00003430222,"domain_scores_codex":[0.9993175,0.00003063345,0.0001741159,0.0002799601,0.00005177475,0.0001460189],"domain_scores_gemma":[0.9988104,0.000146512,0.00007194963,0.0007323551,0.0001639143,0.00007486408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006560368,0.0002032984,0.002738843,0.0003042232,0.0001762889,0.000001036908,0.0003179098,9.094688e-7,0.931366,0.0173042,0.03158266,0.01534859],"study_design_scores_gemma":[0.001188226,0.001125209,0.007229269,0.0004267444,0.000685639,0.0001603696,0.0003153052,0.0007265122,0.1729378,0.0007202443,0.8138879,0.0005967593],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6109696,0.02835412,0.00008030004,0.3553135,0.0007220068,0.002377992,0.0001746949,0.000226058,0.00178168],"genre_scores_gemma":[0.9886841,0.001890449,0.006684568,0.002009733,0.0002510239,0.000002022067,0.0001747672,0.00001758757,0.0002858027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7823052,"threshold_uncertainty_score":0.3584967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05040571091131332,"score_gpt":0.31993623118786,"score_spread":0.2695305202765467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}