{"id":"W3092720153","doi":"10.1001/jama.2020.15922","title":"Effect of Vericiguat vs Placebo on Quality of Life in Patients With Heart Failure and Preserved Ejection Fraction","year":2020,"lang":"en","type":"article","venue":"JAMA","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":275,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Canadian VIGOUR Centre","funders":"National Heart, Lung, and Blood Institute; Relypsa; Respicardia; American Regent; National Institutes of Health; Cytokinetics; Eisai; MyoKardia; Novo Nordisk; Daiichi-Sankyo; Gilead Sciences; Servier; Pfizer; Moderna; Impulse Dynamics; Boston Scientific Corporation; Alnylam Pharmaceuticals; Sanofi; Bristol-Myers Squibb; AstraZeneca; Sanofi Pasteur; Celladon Corporation; Amgen; Vifor Pharma; GlaxoSmithKline; LivaNova; CSL Limited; Ironwood Pharmaceuticals, Incorporated","keywords":"Medicine; Ejection fraction; Heart failure; Placebo; Internal medicine; Randomized controlled trial; Quality of life (healthcare); Decompensation; Cardiology; Atrial fibrillation; Natriuretic peptide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001466919,0.001174132,0.002378674,0.0003271523,0.0002703884,0.0006458046,0.0006287948,0.00149217,0.005388589],"category_scores_gemma":[0.001695287,0.0004651847,0.001279474,0.0003014544,0.0007116511,0.0006175672,0.0003212429,0.001574846,0.0004685951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004220081,"about_ca_system_score_gemma":0.0004997475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006322941,"about_ca_topic_score_gemma":0.001108617,"domain_scores_codex":[0.9994614,0.0003236679,0.00003752235,0.00008250435,0.00003009763,0.00006476632],"domain_scores_gemma":[0.9991292,0.0003540901,0.0002385071,0.00004245258,0.00003679799,0.0001989419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9820451,0.003534741,0.0007267822,0.0003980401,0.0003892998,0.00001552828,0.00002264645,0.0001345716,0.001317571,0.00002860738,0.0002365526,0.01115071],"study_design_scores_gemma":[0.8463331,0.146306,0.005288797,0.00004789133,0.0005653856,0.00002879162,0.00002829831,0.0004032732,0.0006435823,0.00006624774,0.0002762163,0.00001256535],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911903,0.005671293,0.0001760065,0.0003899914,0.0003591693,0.0007013211,0.0004835853,0.00005255283,0.0009757697],"genre_scores_gemma":[0.9954115,0.001605254,0.0004294073,0.0003805121,0.0002423591,0.0008439052,0.0003204722,0.000005898682,0.00076089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005388589,"threshold_uncertainty_score":0.01802665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01519813644395609,"score_gpt":0.2739801644029368,"score_spread":0.2587820279589807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}