{"id":"W3092730512","doi":"10.1371/journal.pgen.1009070","title":"PE homeostasis rebalanced through mitochondria-ER lipid exchange prevents retinal degeneration in Drosophila","year":2020,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Directorate for Biological Sciences; Institute of Genetics; National Natural Science Foundation of China","keywords":"Biology; Cell biology; Mitochondrion; Endoplasmic reticulum; Retinal degeneration; Visual phototransduction; Phosphatidylethanolamine; Biochemistry; Retinal; Phospholipid; Phosphatidylcholine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001600359,0.0003837382,0.0002932691,0.0004329931,0.0002830326,0.0003006276,0.0003468645,0.000500172,0.001320828],"category_scores_gemma":[0.0001399924,0.0002174517,0.0002624059,0.0001718858,0.000400762,0.0002443311,0.0003288635,0.0006705975,0.0003613885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006004563,"about_ca_system_score_gemma":0.0003431856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002386819,"about_ca_topic_score_gemma":0.004666422,"domain_scores_codex":[0.9998602,0.00002412953,0.00002442009,0.00003684507,0.00002741877,0.0000269552],"domain_scores_gemma":[0.9998059,0.00003292126,0.00005981168,0.0000180253,0.00001467001,0.00006874572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001360047,0.00003763339,0.0001601234,0.00004193494,0.000007407231,0.00009539403,0.00002371214,0.0001288731,0.9976124,0.0002160293,0.00006070082,0.0014799],"study_design_scores_gemma":[0.00006496757,0.0003324445,0.005256262,0.00002164212,0.00002842817,0.0002719298,0.00007471243,0.002057048,0.9879975,0.000138467,0.003743296,0.0000133306],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938033,0.0009451898,0.002314182,0.0002083642,0.00004289996,0.00004641286,0.0006565453,0.0001556447,0.001827408],"genre_scores_gemma":[0.989517,0.0007878245,0.003151696,0.0001180939,0.000009059984,0.00005835806,0.0004873384,0.00008058152,0.005789919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002386819,"threshold_uncertainty_score":0.004745841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04611834464733996,"score_gpt":0.2868480142777621,"score_spread":0.2407296696304221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}