{"id":"W3092737291","doi":"10.1016/j.cgh.2020.10.019","title":"Efficacy and Safety of Ornithine Phenylacetate for Treating Overt Hepatic Encephalopathy in a Randomized Trial","year":2020,"lang":"en","type":"article","venue":"Clinical Gastroenterology and Hepatology","topic":"Liver Disease and Transplantation","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Allergan; Shire; Exelixis; Merck; AbbVie; Mallinckrodt Pharmaceuticals; Gilead Sciences; Novartis; Bayer","keywords":"Medicine; Hepatic encephalopathy; Lactulose; Placebo; Cirrhosis; Adverse effect; Gastroenterology; Internal medicine; Rifaximin; Population; Clinical endpoint; Randomized controlled trial; Liver disease; Pediatrics; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006388549,0.0001218794,0.001296336,0.00005119676,0.00002715393,0.000002267857,0.00003619341,0.0001351232,0.00001942592],"category_scores_gemma":[0.000487159,0.0000960521,0.0001473616,0.00004100383,0.0004429519,0.00003263904,0.0000224948,0.0001819785,9.481752e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004583462,"about_ca_system_score_gemma":0.00004455184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001438555,"about_ca_topic_score_gemma":0.00003516324,"domain_scores_codex":[0.9980737,0.0004875478,0.0008933866,0.0003054374,0.00004789194,0.0001920418],"domain_scores_gemma":[0.9977223,0.001823583,0.0001876529,0.0000747438,0.00003594304,0.0001558189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5973192,0.0001541872,0.4012998,0.000134052,0.0001813031,0.00002549353,0.0003059721,5.775567e-7,0.00002594562,0.00009711064,0.00000475873,0.0004516763],"study_design_scores_gemma":[0.8807122,0.005550847,0.1085674,0.00006300517,0.001053451,0.00003948273,0.00003773521,0.003635045,0.00001725453,0.0002642504,0.00001118662,0.00004814353],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941215,0.0002362484,0.001673636,0.002542685,0.000092952,0.001265125,0.00001992605,0.00001449599,0.00003345084],"genre_scores_gemma":[0.9956514,0.0009417125,0.0007337212,0.002466084,0.00008763001,0.00005938425,0.00004829026,0.000007996096,0.000003800789],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2927323,"threshold_uncertainty_score":0.3916891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03379235545656152,"score_gpt":0.3354141170480848,"score_spread":0.3016217615915233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}