{"id":"W3092782632","doi":"10.3390/cancers12102953","title":"The CINs of Polo-Like Kinase 1 in Cancer","year":2020,"lang":"en","type":"review","venue":"Cancers","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"Canadian Institutes of Health Research; Cancer Research Society; Saskatchewan Cancer Agency; University of Saskatchewan","keywords":"PLK1; Centrosome; Mitosis; Cytokinesis; Chromosome instability; Biology; Cancer research; Kinase; Cancer; Cell biology; Cancer cell; Polo-like kinase; DNA repair; Genome instability; Aurora B kinase; DNA damage; Cell cycle; Genetics; DNA; Chromosome; Cell division; Cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000376681,0.0008513526,0.0008996856,0.001804712,0.0002371457,0.0007245056,0.0007937768,0.0007373246,0.003532726],"category_scores_gemma":[0.0004432782,0.0002250463,0.000394385,0.001545009,0.0003468657,0.001037109,0.0006751174,0.001790993,0.002265753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006045215,"about_ca_system_score_gemma":0.0007550245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008224769,"about_ca_topic_score_gemma":0.001667027,"domain_scores_codex":[0.9998938,0.00001620926,0.00001342944,0.0000179527,0.00004449994,0.00001406755],"domain_scores_gemma":[0.9998504,0.00005431262,0.00002323802,0.000005385221,0.00004155438,0.00002500367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008522419,0.00005547395,0.00012837,0.01068392,0.00006841944,0.0001727798,0.00003618941,0.0004209256,0.002138592,0.003565738,0.04502143,0.9376228],"study_design_scores_gemma":[0.00001203426,0.00005366164,0.0004477588,0.001454052,0.00005170023,0.0007613824,0.00001793452,0.00005965843,0.0003487831,0.00127137,0.9955129,0.000008789194],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000112069,0.9978932,0.0001088331,0.0002325563,0.0002712557,0.000004439817,0.00001767487,0.00001140838,0.001348706],"genre_scores_gemma":[0.0007488857,0.9975892,0.0001306552,0.0001903715,0.0001679744,0.000006213159,0.00004975628,0.000002161506,0.001114778],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003532726,"threshold_uncertainty_score":0.01181817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02229756231067799,"score_gpt":0.3178291622563016,"score_spread":0.2955315999456237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}