{"id":"W3092782632","doi":"10.3390/cancers12102953","title":"The CINs of Polo-Like Kinase 1 in Cancer","year":2020,"lang":"en","type":"review","venue":"Cancers","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"Canadian Institutes of Health Research; Cancer Research Society; Saskatchewan Cancer Agency; University of Saskatchewan","keywords":"PLK1; Centrosome; Mitosis; Cytokinesis; Chromosome instability; Biology; Cancer research; Kinase; Cancer; Cell biology; Cancer cell; Polo-like kinase; DNA repair; Genome instability; Aurora B kinase; DNA damage; Cell cycle; Genetics; DNA; Chromosome; Cell division; Cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006661865,0.0002002589,0.0005010138,0.00002774872,0.00003252359,0.000008181104,0.000341458,0.0002189818,0.00001095389],"category_scores_gemma":[0.0000248728,0.0001426371,0.0002405419,0.0001486848,0.00009505341,7.4065e-7,0.0001024502,0.0001708128,0.000003367084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002711396,"about_ca_system_score_gemma":0.001724766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004221415,"about_ca_topic_score_gemma":0.001642167,"domain_scores_codex":[0.9990947,0.00005592035,0.0002983665,0.0002860214,0.000063795,0.0002011672],"domain_scores_gemma":[0.9993894,0.00001490339,0.0001897242,0.0003267046,0.00002741577,0.0000519254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001611496,0.000005531155,0.00001153667,0.002131449,0.0001614394,0.000005283696,0.00002567734,0.00002393343,0.0006723602,0.00004573214,0.008801552,0.9880994],"study_design_scores_gemma":[0.0001025907,0.00004384547,0.000001332104,0.0009297366,0.00009622375,0.000002315788,0.00001894282,0.000005612458,0.0002475932,0.00000213469,0.9983986,0.0001510862],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001282526,0.9985934,0.00001005517,0.00003450915,0.0003863761,0.000308084,0.000162186,0.000002907866,0.0003741638],"genre_scores_gemma":[0.0001405353,0.9987491,0.00001425417,0.0001337489,0.000216007,0.0001325548,0.00009773802,0.00003250422,0.0004835427],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.989597,"threshold_uncertainty_score":0.5816571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02229756231067799,"score_gpt":0.3178291622563016,"score_spread":0.2955315999456237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}