{"id":"W3092820072","doi":"10.1016/j.neuint.2020.104881","title":"Dickkopf-related protein-1 inhibition attenuates amyloid-beta pathology associated to Alzheimer's disease","year":2020,"lang":"en","type":"article","venue":"Neurochemistry International","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Scottish Rite Charitable Foundation of Canada","keywords":"DKK1; Wnt signaling pathway; Amyloid precursor protein; Pathogenesis; Amyloid beta; Alzheimer's disease; Biology; Endocrinology; GSK3B; Catenin; Amyloid precursor protein secretase; Internal medicine; Phosphorylation; Cell biology; Signal transduction; Neuroscience; Medicine; GSK-3; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000738593,0.0002124852,0.0001332758,0.00002734578,0.00006986666,0.00004392833,0.0003168605,0.000147268,0.0003446498],"category_scores_gemma":[0.0002757486,0.0002324475,0.0001029735,0.0001225422,0.00006172871,0.000008177082,0.0002074866,0.0001632134,0.00009591322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002579131,"about_ca_system_score_gemma":0.0001047754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001704466,"about_ca_topic_score_gemma":7.354429e-7,"domain_scores_codex":[0.9985696,0.0000372729,0.0002972661,0.0005663996,0.0002902856,0.0002391906],"domain_scores_gemma":[0.99923,0.00000915295,0.0001267176,0.0001656385,0.0002020071,0.0002664723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000174851,0.00006105367,0.002776318,0.00000763821,0.0001217348,0.00005153187,0.00005384449,0.000143554,0.986154,0.00002198649,0.01018663,0.0002468968],"study_design_scores_gemma":[0.0007338118,0.00009648682,0.004986182,0.00003480936,0.00003977371,0.00001047602,0.00001825524,0.000120536,0.9771564,0.00006442329,0.01641544,0.0003234013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884336,0.0001497835,0.0001813054,0.00833848,0.0002613001,0.0002201347,0.0001100364,0.00006525483,0.00224008],"genre_scores_gemma":[0.9934805,0.00001707102,0.0001108,0.003357052,0.0004019299,0.0001008326,0.001446402,0.00003008906,0.001055302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008997559,"threshold_uncertainty_score":0.9478933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01401601614462993,"score_gpt":0.2412403015969601,"score_spread":0.2272242854523302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}