{"id":"W3092841540","doi":"10.1016/s0140-6736(20)32014-6","title":"Efficacy, immunogenicity, and safety of a plant-derived, quadrivalent, virus-like particle influenza vaccine in adults (18–64 years) and older adults (≥65 years): two multicentre, randomised phase 3 trials","year":2020,"lang":"en","type":"article","venue":"The Lancet","topic":"Transgenic Plants and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":192,"is_retracted":false,"has_abstract":false,"ca_institutions":"Medicago (Canada); McGill University Health Centre","funders":"","keywords":"Medicine; Placebo; Seasonal influenza; Influenza A virus; Randomized controlled trial; Vaccination; Body mass index; Influenza vaccine; Pediatrics; Internal medicine; Immunology; Virus; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002598548,0.001542483,0.002429829,0.0002630592,0.0004217196,0.0009070129,0.0007392365,0.002570302,0.002881485],"category_scores_gemma":[0.002151225,0.0006738012,0.002436357,0.0003596557,0.001282043,0.001078767,0.0003833833,0.003349508,0.0005344995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001019186,"about_ca_system_score_gemma":0.0008497625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001442902,"about_ca_topic_score_gemma":0.001563417,"domain_scores_codex":[0.9992579,0.0003850111,0.00005284281,0.0001198213,0.00006378456,0.0001207109],"domain_scores_gemma":[0.9987632,0.0004197129,0.0003095441,0.00008487466,0.00009598509,0.0003267552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9720113,0.005148287,0.0010314,0.0006446982,0.001196566,0.00002603409,0.00009538871,0.0003259612,0.00521476,0.00008220301,0.0003926595,0.01383075],"study_design_scores_gemma":[0.7488326,0.2427841,0.005064096,0.00006810009,0.001018546,0.00005224777,0.00005872756,0.0002980899,0.0009108172,0.0002281902,0.0006581172,0.00002636977],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921533,0.00410558,0.0004627683,0.0003727032,0.0002477349,0.00145568,0.0004685891,0.00002804626,0.0007055378],"genre_scores_gemma":[0.9913872,0.002492403,0.0008541275,0.0007760506,0.0002517645,0.00211762,0.0006643276,0.00001316569,0.001443387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002881485,"threshold_uncertainty_score":0.01374263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03304976075600642,"score_gpt":0.3119582914230273,"score_spread":0.2789085306670209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}