{"id":"W3092841540","doi":"10.1016/s0140-6736(20)32014-6","title":"Efficacy, immunogenicity, and safety of a plant-derived, quadrivalent, virus-like particle influenza vaccine in adults (18–64 years) and older adults (≥65 years): two multicentre, randomised phase 3 trials","year":2020,"lang":"en","type":"article","venue":"The Lancet","topic":"Transgenic Plants and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":192,"is_retracted":false,"has_abstract":false,"ca_institutions":"Medicago (Canada); McGill University Health Centre","funders":"","keywords":"Medicine; Placebo; Seasonal influenza; Influenza A virus; Randomized controlled trial; Vaccination; Body mass index; Influenza vaccine; Pediatrics; Internal medicine; Immunology; Virus; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003491987,0.0001258899,0.0004312341,0.00001250088,0.00003322862,0.00001512525,0.000184063,0.00006146685,0.0000338147],"category_scores_gemma":[0.0001117514,0.00009678209,0.00006202259,0.00007380732,0.00005263565,0.000005519404,0.00008181083,0.00009458235,0.000004144906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003130261,"about_ca_system_score_gemma":0.00001929029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001124683,"about_ca_topic_score_gemma":0.0001599426,"domain_scores_codex":[0.9989005,0.0001515179,0.000401694,0.0002622977,0.00008176943,0.0002022775],"domain_scores_gemma":[0.9993805,0.0001156379,0.0001357531,0.0002706382,0.00001695439,0.0000805153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.08370634,0.000315737,0.003941474,0.00008302821,0.0001992438,0.000005720659,0.002389408,0.00005459506,0.8994184,0.00002832789,0.001514777,0.008343],"study_design_scores_gemma":[0.4980685,0.0004541072,0.2881376,0.0002751344,0.0002326792,0.00002071006,0.0003987796,0.001477041,0.1915907,0.00001906024,0.01881918,0.0005064979],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960697,0.00181282,0.00007636294,0.0003897126,0.00002178891,0.0008228692,0.0007809145,0.00001166557,0.00001418485],"genre_scores_gemma":[0.9967256,0.002255449,0.00010502,0.0005928728,0.000170118,0.00003229535,0.0001011498,0.00001272868,0.00000480458],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7078277,"threshold_uncertainty_score":0.3946659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03304976075600642,"score_gpt":0.3119582914230273,"score_spread":0.2789085306670209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}