{"id":"W3092862007","doi":"10.1074/jbc.ra120.014831","title":"Interrogation of kinase genetic interactions provides a global view of PAK1-mediated signal transduction pathways","year":2020,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"National Institutes of Health; National Human Genome Research Institute; National Research Foundation of Korea","keywords":"Biology; PAK1; Signal transduction; Cell biology; Genetic screen; Kinase; Cancer research; Cell cycle; Genetics; Cell; Gene; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001320152,0.0005616187,0.0003000955,0.0006134625,0.0004258669,0.0007260861,0.0002601051,0.0003586744,0.002278898],"category_scores_gemma":[0.0001403492,0.0002320308,0.0003215803,0.0003061896,0.0004821084,0.0009484654,0.0003459182,0.001385117,0.0005337549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000547322,"about_ca_system_score_gemma":0.0002204882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005687895,"about_ca_topic_score_gemma":0.001616273,"domain_scores_codex":[0.9999124,0.00001113721,0.000003909602,0.00002885751,0.00002471852,0.00001906392],"domain_scores_gemma":[0.9999086,0.00002337826,0.00002591413,0.00001181201,0.00001129501,0.00001903774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005857215,0.000009870467,0.000489429,0.00006609957,0.00001275146,0.00005580073,0.00002119502,0.0009713724,0.99306,0.001167531,0.00008426896,0.004003068],"study_design_scores_gemma":[0.00001813182,0.000139851,0.01595185,0.00002225198,0.00008583703,0.0008976323,0.0001462947,0.01270032,0.9586762,0.003400616,0.007927809,0.00003324528],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9153615,0.005950715,0.0607104,0.0008728106,0.00006521156,0.00003357351,0.001215066,0.0004327782,0.01535793],"genre_scores_gemma":[0.980881,0.003065025,0.01180916,0.0001328824,0.00002132762,0.00004407053,0.0005781167,0.00007075066,0.00339774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002278898,"threshold_uncertainty_score":0.007623672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0223038575840915,"score_gpt":0.2502601873267403,"score_spread":0.2279563297426488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}