{"id":"W3092935066","doi":"10.1161/circulationaha.119.041213","title":"Innate Immune Nod1/RIP2 Signaling Is Essential for Cardiac Hypertrophy but Requires Mitochondrial Antiviral Signaling Protein for Signal Transductions and Energy Balance","year":2020,"lang":"en","type":"article","venue":"Circulation","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Mary's University; University Health Network; University of Toronto; McMaster University; University of Ottawa","funders":"","keywords":"Medicine; Cardiac hypertrophy; Innate immune system; Signal transduction; NOD1; Mitochondrion; Immune system; Cell biology; Muscle hypertrophy; Immunology; Internal medicine; Biology; NOD2","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001346837,0.0002171644,0.0005156286,0.0000861034,0.0002766484,0.00007436735,0.00004830853,0.0001687043,0.00001063049],"category_scores_gemma":[0.00006056625,0.0002151955,0.0004797427,0.0001748938,0.00006296582,0.000209998,0.00001551986,0.0001187398,9.696058e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004382647,"about_ca_system_score_gemma":0.00009019944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005113636,"about_ca_topic_score_gemma":4.065896e-7,"domain_scores_codex":[0.9984584,0.00004591044,0.0004673074,0.0004923482,0.0002412748,0.0002947942],"domain_scores_gemma":[0.9993063,0.00006571897,0.0001406384,0.0001385914,0.0002352677,0.0001135226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006887637,0.00002816693,0.0003495441,0.0002852215,0.0001603582,7.300656e-7,0.0006408663,0.001560071,0.9910437,0.0002356112,0.00004116007,0.004965782],"study_design_scores_gemma":[0.004113763,0.000328334,0.001313696,0.0003547689,0.0006976107,0.00001050279,0.0002889158,0.1972363,0.7924967,0.0004747786,0.002199529,0.0004851445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7594267,0.001330531,0.2361774,0.001411891,0.0004573632,0.0009672524,0.0001301164,0.00007445383,0.00002430363],"genre_scores_gemma":[0.9890991,0.00003507924,0.007123247,0.0001655585,0.003064313,0.0001684854,0.0002571688,0.00005740554,0.00002965663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2296724,"threshold_uncertainty_score":0.8775418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01979348177848109,"score_gpt":0.2462963686963783,"score_spread":0.2265028869178972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}