{"id":"W3092947646","doi":"10.1007/s12015-020-10054-1","title":"Low-Dose Triptolide Enhanced Activity of Idarubicin Against Acute Myeloid Leukemia Stem-like Cells Via Inhibiting DNA Damage Repair Response","year":2020,"lang":"en","type":"article","venue":"Stem Cell Reviews and Reports","topic":"Natural Compounds in Disease Treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Positive Living Society of British Columbia","funders":"Young Scientists Fund; National Natural Science Foundation of China","keywords":"Myeloid leukemia; Idarubicin; CD34; Stem cell; CD38; Cancer research; Leukemia; Medicine; Pharmacology; Immunology; Cytarabine; Biology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006743355,0.0001700349,0.0002877103,0.0001514463,0.00007722405,0.0001879044,0.0001488247,0.0001766041,0.001967326],"category_scores_gemma":[0.00008076283,0.00007029581,0.0001671686,0.0001016655,0.0001244467,0.0001318016,0.0001063053,0.0005095775,0.0003248816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001273918,"about_ca_system_score_gemma":0.0002671161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00024402,"about_ca_topic_score_gemma":0.0004187807,"domain_scores_codex":[0.9999524,0.000008869444,0.00000569664,0.000008109966,0.000009561427,0.00001538424],"domain_scores_gemma":[0.9999696,0.00000956222,0.000004480103,0.000004235188,0.000003685271,0.000008367316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009869601,0.0001357243,0.0003147245,0.0001243418,0.0000182148,0.00009495282,0.00002542309,0.0002602748,0.9897441,0.0002122438,0.0002690729,0.007813996],"study_design_scores_gemma":[0.0001283712,0.001782776,0.002659278,0.000009596429,0.00004752872,0.0002816431,0.00003093331,0.00075574,0.9906688,0.00008915137,0.003539261,0.000006917323],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929475,0.002768461,0.00132692,0.000141159,0.00009739964,0.000046548,0.000415063,0.00009749434,0.002159381],"genre_scores_gemma":[0.9963531,0.001049186,0.0007316807,0.00006165211,0.00001432817,0.00002161746,0.000454265,0.000007120324,0.001307043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001967326,"threshold_uncertainty_score":0.006581426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01891686996954632,"score_gpt":0.2690906726421661,"score_spread":0.2501738026726197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}