{"id":"W3092962009","doi":"10.71781/11766","title":"Lactam-peptide modulators of biased interlukin-1 receptor signaling for mitigating inflammation without compromising immuno-vigilance","year":2019,"lang":"en","type":"dissertation","venue":"Open MIND","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research; Université de Montréal; Centre in Green Chemistry and Catalysis","keywords":"Inflammation; Receptor; Interleukin 6; Vigilance (psychology); Peptide; Signal transduction; Chemistry; Medicine; Pharmacology; Immunology; Biology; Internal medicine; Neuroscience; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002360732,0.0003837747,0.0002249959,0.0001465665,0.0001037972,0.0003735726,0.0002575837,0.000385493,0.002668014],"category_scores_gemma":[0.0002685791,0.0001290334,0.0002390592,0.0001045666,0.0001706899,0.0003206365,0.0002376654,0.0008054187,0.0007513604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002271871,"about_ca_system_score_gemma":0.0002247243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001512684,"about_ca_topic_score_gemma":0.0003239747,"domain_scores_codex":[0.9998622,0.00003211981,0.000009812614,0.00002716874,0.00003205164,0.00003670822],"domain_scores_gemma":[0.9999129,0.00001870471,0.00002832637,0.000007450158,0.00001130288,0.00002128738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002927301,0.00008842335,0.0001791249,0.000135068,0.00001327349,0.0000731143,0.00002009756,0.000236556,0.9867238,0.0003204386,0.000193769,0.01172351],"study_design_scores_gemma":[0.0002184826,0.002902273,0.001756018,0.00003349542,0.00005308722,0.0004284892,0.00005032778,0.00191168,0.9746653,0.0002021627,0.01775814,0.00002055971],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9585648,0.01719244,0.01488025,0.0007221063,0.0003676238,0.0002404019,0.0004212695,0.0002334728,0.007377692],"genre_scores_gemma":[0.9750137,0.006440127,0.01112165,0.0005664477,0.00005723314,0.0002332254,0.0002945392,0.00002853347,0.006244655],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.002668014,"threshold_uncertainty_score":0.008925438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0346625286234136,"score_gpt":0.3350943318183035,"score_spread":0.3004318031948899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}