{"id":"W3092984710","doi":"10.1186/s12987-020-00226-z","title":"Identification and in vivo characterization of a brain-penetrating nanobody","year":2020,"lang":"en","type":"article","venue":"Fluids and Barriers of the CNS","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Vlaamse regering; Vlaams Instituut voor Biotechnologie; Onderzoeksraad, KU Leuven; Alzheimer Society; KU Leuven; Fonds Wetenschappelijk Onderzoek; Medical Research Council; Cure Alzheimer's Fund","keywords":"Neurotensin; Transferrin receptor; Transcytosis; In vivo; Receptor; Transferrin; Blood–brain barrier; Pharmacology; Medicine; Neuropeptide; Biology; Internal medicine; Central nervous system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001202012,0.0000441263,0.0001189544,0.00002758549,0.00003617768,0.000005905787,0.00004478621,0.00002603031,0.00005113002],"category_scores_gemma":[0.0002144765,0.00002953732,0.00002410247,0.0001190504,0.0001004877,0.00003695688,0.00004592409,0.00005828243,2.902788e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003565591,"about_ca_system_score_gemma":0.00003262838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002590122,"about_ca_topic_score_gemma":0.000003642218,"domain_scores_codex":[0.9995233,0.00002715255,0.0001700049,0.00009058802,0.000122665,0.0000662716],"domain_scores_gemma":[0.9997543,0.00003295284,0.00004586546,0.0000631752,0.00003530754,0.00006840573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001074441,0.000006834063,0.06458142,0.0001545094,0.000009851412,8.186088e-7,0.0007188278,2.412548e-7,0.9334713,0.0001920251,0.0001190744,0.0006376393],"study_design_scores_gemma":[0.0005237262,0.000165077,0.4928049,0.0001322542,0.00001810936,0.000007705828,0.0002573206,0.002427462,0.50236,0.00008702375,0.00116109,0.00005531634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899491,0.0001078584,0.00001906796,0.009579027,0.00002096547,0.0001363934,0.00002539638,0.000002575072,0.0001596174],"genre_scores_gemma":[0.999052,0.0001002543,0.00003810149,0.0003750941,0.00003233963,0.000002083318,0.000003764726,0.000003749071,0.0003926195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4311113,"threshold_uncertainty_score":0.1204497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0154717728554044,"score_gpt":0.2711088671186832,"score_spread":0.2556370942632788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}