{"id":"W3092984710","doi":"10.1186/s12987-020-00226-z","title":"Identification and in vivo characterization of a brain-penetrating nanobody","year":2020,"lang":"en","type":"article","venue":"Fluids and Barriers of the CNS","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Vlaamse regering; Vlaams Instituut voor Biotechnologie; Onderzoeksraad, KU Leuven; Alzheimer Society; KU Leuven; Fonds Wetenschappelijk Onderzoek; Medical Research Council; Cure Alzheimer's Fund","keywords":"Neurotensin; Transferrin receptor; Transcytosis; In vivo; Receptor; Transferrin; Blood–brain barrier; Pharmacology; Medicine; Neuropeptide; Biology; Internal medicine; Central nervous system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002915368,0.0002963315,0.0001957309,0.0002234419,0.0001102194,0.0002684972,0.0001859461,0.0004091431,0.0007092032],"category_scores_gemma":[0.0002235442,0.00007566707,0.0002271135,0.000115901,0.0002050274,0.0002154267,0.0001496863,0.0004974484,0.0005066321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000292327,"about_ca_system_score_gemma":0.0001563294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002830723,"about_ca_topic_score_gemma":0.0002210595,"domain_scores_codex":[0.9998847,0.00001931156,0.000009453918,0.00003018597,0.00003333439,0.00002303051],"domain_scores_gemma":[0.9998266,0.00004322925,0.00004459193,0.00001675384,0.00004267598,0.0000261907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000160627,0.00001241587,0.00004547941,0.00002121184,0.000001734408,0.00001711851,0.000009615133,0.0000366826,0.9992434,0.00003123928,0.00001523178,0.0005498019],"study_design_scores_gemma":[0.000004826663,0.0002728597,0.0008658263,0.00000523757,0.000009463396,0.0002353717,0.00001173308,0.0004950464,0.9964157,0.0000274164,0.00165412,0.000002246898],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9358522,0.002681991,0.0589641,0.0001405636,0.00003915532,0.0001793394,0.000393949,0.0001029795,0.001645762],"genre_scores_gemma":[0.9661993,0.00179756,0.0279174,0.0001236725,0.00001917942,0.0001634962,0.001186105,0.00005397541,0.002539223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007092032,"threshold_uncertainty_score":0.002372503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0154717728554044,"score_gpt":0.2711088671186832,"score_spread":0.2556370942632788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}