{"id":"W3092984943","doi":"10.1016/j.ahj.2020.10.052","title":"Rationale and design of ApoA-I Event Reducing in Ischemic Syndromes II (AEGIS-II): A phase 3, multicenter, double-blind, randomized, placebo-controlled, parallel-group study to investigate the efficacy and safety of CSL112 in subjects after acute myocardial infarction","year":2020,"lang":"en","type":"article","venue":"American Heart Journal","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian VIGOUR Centre; University of Alberta; St. Michael's Hospital","funders":"CSL Behring","keywords":"Medicine; Placebo; Myocardial infarction; Internal medicine; Coronary artery disease; Randomized controlled trial; Multicenter trial; Stroke (engine); Cardiology; Cholesterol; Surgery; Pathology; Multicenter study","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003157769,0.0002024397,0.001489573,0.000224957,0.0001271688,0.00002014012,0.00006762346,0.00003645915,0.00001056616],"category_scores_gemma":[0.0003089769,0.0001384854,0.0002253731,0.0003911924,0.0002463018,0.000123724,0.00009384452,0.000435305,5.477828e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000711911,"about_ca_system_score_gemma":0.000237321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008378486,"about_ca_topic_score_gemma":0.00002828023,"domain_scores_codex":[0.9970345,0.0009576059,0.0009598004,0.0002919648,0.0004890131,0.0002671049],"domain_scores_gemma":[0.9987663,0.0003276005,0.0003109744,0.0002021436,0.00008736861,0.0003056081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.965652,0.0008414945,0.00663322,0.00005821944,0.001254821,0.00006617042,0.01454806,0.001743443,0.005596514,0.000002063274,0.00006016922,0.00354385],"study_design_scores_gemma":[0.972726,0.005126862,0.01427121,0.0003744828,0.0007779698,0.0005474878,0.002870155,0.002549114,0.0003603251,0.000004996803,0.0001978141,0.00019353],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865692,0.001410853,0.001081756,0.004058176,0.00005564257,0.006807306,0.000003933866,0.000006673977,0.000006433937],"genre_scores_gemma":[0.9959921,0.0009593771,0.001771478,0.000773447,0.0001566743,0.000319736,0.000002749635,0.00001949294,0.000004990894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01167791,"threshold_uncertainty_score":0.5647269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02853460989701299,"score_gpt":0.3109898858539356,"score_spread":0.2824552759569225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}