{"id":"W3092997453","doi":"10.1002/alz.12211","title":"Long genes are more frequently affected by somatic mutations and show reduced expression in Alzheimer's disease: Implications for disease etiology","year":2020,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Petro Geotech (Canada)","funders":"National Institute on Aging; Radboud Universiteit; National Institute of Neurological Disorders and Stroke; Radboud Universitair Medisch Centrum; National Alliance for Research on Schizophrenia and Depression","keywords":"Somatic cell; Gene; Disease; Biology; Pathogenesis; Genetics; Mutation; Etiology; Gene expression; Immunology; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006585685,0.0001973389,0.0001698626,0.00003246569,0.0001456895,0.00004054232,0.0001731373,0.0001040908,0.00001525706],"category_scores_gemma":[0.0000263079,0.0001965601,0.00007823918,0.00007602126,0.00009118977,0.00001461384,0.0001170151,0.00006815914,0.000003419577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002409914,"about_ca_system_score_gemma":0.00006043499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003929803,"about_ca_topic_score_gemma":0.00001321652,"domain_scores_codex":[0.9989191,0.00004945509,0.0003117943,0.0003820461,0.00006164719,0.0002759981],"domain_scores_gemma":[0.9991804,0.00002189242,0.000155309,0.00028418,0.00004940846,0.0003087682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006007231,0.0005868953,0.09764795,0.0001631768,0.008280413,0.00001070471,0.0006817559,0.001286707,0.7709902,0.0003660868,0.05662064,0.06276478],"study_design_scores_gemma":[0.006062459,0.0005084157,0.8147003,0.0001773303,0.02006336,0.0000109724,0.0005397903,0.02545545,0.1110929,0.003015071,0.01605442,0.002319528],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5829086,0.3744869,0.02675795,0.01200118,0.000202651,0.002419038,0.001123395,0.00006519756,0.00003514294],"genre_scores_gemma":[0.9938805,0.0003594295,0.001881272,0.0007941647,0.0001110925,0.0003681364,0.002574465,0.00002897769,0.0000019962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7170523,"threshold_uncertainty_score":0.8015489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01885985563078245,"score_gpt":0.2680719566125702,"score_spread":0.2492121009817877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}